{"created":"2023-06-20T16:50:50.997066+00:00","id":23425,"links":{},"metadata":{"_buckets":{"deposit":"4ff5a07c-ea11-4745-915e-9ae69d15485e"},"_deposit":{"created_by":3,"id":"23425","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23425"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023425","sets":["14:923:1519:4826"]},"author_link":["43884","43885","43888","43889","43887","43886"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-12-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"25","bibliographicPageStart":"17","bibliographicVolumeNumber":"47","bibliographic_titles":[{},{"bibliographic_title":"ACTA MEDICA KINDAI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Abstract] Background: Although adipokines are known to contribute to the pathogenesis of diabetic kidney disease (DKD), pathological significance of nesfatin-1, an adipokine in DKD remains unclear. We studied the possible associations between serum nesfatin-1 concentrations and histological renal damages in 56 persons with biopsy-proved DKD.\nMethods: The relation between serum nesfatin-1 concentrations, clinical parameters and renal histological damage were cross-sectionally investigated.\nResults: Serum nesfatin-1 concentrations showed a significant negative correlation with age, total cholesterol, and high-density lipoprotein cholesterol, but not with other clinical parameters. Persons were divided into the following three groups based on serum nesfatin-1 concentrations (pg/mL): low- (log average: 1.99), normal- (log average: 3.05), and high-group (log average: 3.60). Histological analysis of tubulointerstitial lesions showed higher interstitial fibrosis and tubular atrophy scores and more severe interstitial infiltration in the group with low serum nesfatin-1 concentrations than in the other groups.\nConclusion: Serum nesfatin-1 concentrations showed a strong correlation with diabetic tubulointerstitial damage level, suggesting its clinical utility as a biomarker for histological injury in DKD.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15100/00023396","subitem_identifier_reg_type":"JaLC"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"The Kindai University Medical Association"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866092","subitem_source_identifier_type":"ISSN"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"},{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"},{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"},{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"},{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"},{"subitem_text_value":"Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyake, Sayoko"},{"creatorName":"ミヤケ, サヨコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakatani, Yoshihisa"},{"creatorName":"ナカタニ, ヨシヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Yukihito"},{"creatorName":"ナカノ, ユキヒト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Norihiro"},{"creatorName":"コバヤシ, ノヒリロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimizu, Kazuyuki"},{"creatorName":"シミズ, カズユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arima, Shuji"},{"creatorName":"アリマ, シュウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43889","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-21"}],"displaytype":"detail","filename":"AA0050842X-20221200-0017.pdf","filesize":[{"value":"839.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA0050842X-20221200-0017.pdf","url":"https://kindai.repo.nii.ac.jp/record/23425/files/AA0050842X-20221200-0017.pdf"},"version_id":"5ee380ee-fdf5-4c14-bc14-133aa1e7d293"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nesfatin-1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Tubulointerstitial damage","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Diabetic kidney disease","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Adipokine","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Nucleobindin-2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Type 2 diabetes mellitus","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Original> Nesfatin-1 and tubulointerstitial damage in diabetic kidney disease: A possible biomarker for the histological severity","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Original> Nesfatin-1 and tubulointerstitial damage in diabetic kidney disease: A possible biomarker for the histological severity","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["4826"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-12-21"},"publish_date":"2022-12-21","publish_status":"0","recid":"23425","relation_version_is_last":true,"title":["<Original> Nesfatin-1 and tubulointerstitial damage in diabetic kidney disease: A possible biomarker for the histological severity"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T18:44:58.619360+00:00"}