| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2022-12-21 |
| タイトル |
|
|
タイトル |
<Original> Nesfatin-1 and tubulointerstitial damage in diabetic kidney disease: A possible biomarker for the histological severity |
|
言語 |
en |
| 著者 |
Miyake, Sayoko
Nakatani, Yoshihisa
Nakano, Yukihito
Kobayashi, Norihiro
Shimizu, Kazuyuki
Arima, Shuji
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
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主題 |
Nesfatin-1, Tubulointerstitial damage, Diabetic kidney disease, Adipokine, Nucleobindin-2, Type 2 diabetes mellitus |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15100/00023396 |
|
ID登録タイプ |
JaLC |
| 著者所属(翻訳) |
|
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者所属(翻訳) |
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者所属(翻訳) |
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者所属(翻訳) |
|
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者所属(翻訳) |
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
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Division of Nephrology, Department of Internal Medicine, Kindai University Faculty of Medicine |
| 版 |
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出版タイプ |
NA |
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出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
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出版者 |
The Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 47,
号 2,
p. 17-25,
発行日 2022-12-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03866092 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Background: Although adipokines are known to contribute to the pathogenesis of diabetic kidney disease (DKD), pathological significance of nesfatin-1, an adipokine in DKD remains unclear. We studied the possible associations between serum nesfatin-1 concentrations and histological renal damages in 56 persons with biopsy-proved DKD.
Methods: The relation between serum nesfatin-1 concentrations, clinical parameters and renal histological damage were cross-sectionally investigated.
Results: Serum nesfatin-1 concentrations showed a significant negative correlation with age, total cholesterol, and high-density lipoprotein cholesterol, but not with other clinical parameters. Persons were divided into the following three groups based on serum nesfatin-1 concentrations (pg/mL): low- (log average: 1.99), normal- (log average: 3.05), and high-group (log average: 3.60). Histological analysis of tubulointerstitial lesions showed higher interstitial fibrosis and tubular atrophy scores and more severe interstitial infiltration in the group with low serum nesfatin-1 concentrations than in the other groups.
Conclusion: Serum nesfatin-1 concentrations showed a strong correlation with diabetic tubulointerstitial damage level, suggesting its clinical utility as a biomarker for histological injury in DKD. |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20221200-0017.pdf (839.6 kB)
