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<Original> Comparison with regional glucose metabolism, amyloid deposition and tau deposition between dementia with Lewy bodies and Alzheimer disease brains
https://doi.org/10.15100/00023395
https://doi.org/10.15100/0002339543861d65-fa70-44e5-856f-1baa5f69c8e5
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AA0050842X-20221200-0011.pdf (1.7 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||||||||||
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| 公開日 | 2022-12-21 | |||||||||||||||||
| タイトル | ||||||||||||||||||
| タイトル | <Original> Comparison with regional glucose metabolism, amyloid deposition and tau deposition between dementia with Lewy bodies and Alzheimer disease brains | |||||||||||||||||
| 言語 | en | |||||||||||||||||
| 著者 |
Hirayama, Ayumi
× Hirayama, Ayumi
× Yamada, Takahiro
× Ishii, Kazunari
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| 言語 | ||||||||||||||||||
| 言語 | eng | |||||||||||||||||
| キーワード | ||||||||||||||||||
| 主題 | dementia with Lewy bodies (DLB), glucose metabolism, amyloid, tau, positron emission tomography (PET) | |||||||||||||||||
| 資源タイプ | ||||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||||
| 資源タイプ | departmental bulletin paper | |||||||||||||||||
| ID登録 | ||||||||||||||||||
| ID登録 | 10.15100/00023395 | |||||||||||||||||
| ID登録タイプ | JaLC | |||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| Department of Radiology, Kindai University Faculty of Medicine | ||||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine | ||||||||||||||||||
| 著者所属(翻訳) | ||||||||||||||||||
| Department of Radiology, Kindai University Faculty of Medicine: Institute of Advanced Clinical Medicine, Kindai University Faculty of Medicine | ||||||||||||||||||
| 版 | ||||||||||||||||||
| 出版タイプ | NA | |||||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||||||||||
| 出版者 名前 | ||||||||||||||||||
| 出版者 | The Kindai University Medical Association | |||||||||||||||||
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY 巻 47, 号 2, p. 11-16, 発行日 2022-12-01 |
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| ISSN | ||||||||||||||||||
| 収録物識別子タイプ | ISSN | |||||||||||||||||
| 収録物識別子 | 03866092 | |||||||||||||||||
| 抄録 | ||||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||||
| 内容記述 | [Abstract] Purpose: Although some dementia with Lewy bodies (DLB) patients have Alzheimer disease (AD) pathology, there are no reports comparing AD and DLB by amyloid PET and tau PET in the same patient. The aim of this study was to investigate the regional difference of metabolic reduction, amyloid deposition and tau deposition between DLB and AD brain. Methods: Five consecutive subjects with DLB and five age and Mini-mental state examination score matched AD patients, who underwent both fluoro-2-deoxyglucose (FDG)-PET, Pittsburgh compound B (PiB)-amyloid PET and THK5351 (THK)-tau PET, were included in this study. Voxel-based statistical analysis was performed with Statistical Parametric Mapping for comparison with FDG, amyloid and tau accumulation between the DLB and AD brains. Results: FDG PET demonstrated that occipital metabolism in DLB group was significantly lower than that in AD group. PiB PET demonstrated that in the AD group the anterior to posterior cingulate cortices, supplementary motor area, and thalamic amyloid depositions were significantly higher than those in the DLB group. THK PET demonstrated that in the AD group the posterior cingulate cortices, posterior internal capsules, thalamic and peri-brainstem regions tau depositions were significantly higher than those in the DLB group. Conclusions: In the DLB brain, it is suggested that decreased regional glucose metabolism is unrelated to amyloid and tau depositions, and the amyloid and tau depositions in the cingulate gyri and thalamic regions in the AD brain are higher than those in DLB brain. |
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| 内容記述タイプ | Other | |||||||||||||||||
| 内容記述 | application/pdf | |||||||||||||||||
