{"created":"2023-06-20T16:50:49.518969+00:00","id":23383,"links":{},"metadata":{"_buckets":{"deposit":"9e3b59ff-db16-49d8-8f66-9ba080cd2d9f"},"_deposit":{"created_by":3,"id":"23383","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23383"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023383","sets":["14:2667:4819"]},"author_link":["3299","43476"],"control_number":"23383","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07929/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：慢性ストレスが海馬神経新生にどのような影響を与えてうつ病を発症させているのか検討した。その結果以下の知見を得た。（1）慢性ストレスにより情動体験や記憶に関与す る海馬神経新生を低下させる。（2）海馬神経新生に神経特異的RNA結合タンパク質Huが関与している。（3）慢性ストレスにより神経分化に必要なRNA結合タンパク質Huの発現が低下することが示唆された。すなわち，慢性ストレスはHuタンパク質の発現低下を介して，海馬神経新生を低下させることが示唆された。\n研究成果の概要（英文）： We investigated how chronic stress affects hippocampal neurogenesis to cause depression. The following findings were obtained: (1) Chronic stress decreases hippocampal neurogenesis involved in emotional experience and memory.(2) Neuron-specific RNA-binding protein Hu is involved in hippocampal neurogenesis.(3) Chronic stress reduces the expression of RNA-binding protein Hu, which plays an important role in neuronal differentiation. These results suggest that chronic stress reduces hippocampal neurogenesis via decreased expression of Hu protein.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K07929; 研究分野：生化学, 薬理学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FUNAKAMI, Yoshinori"},{"subitem_text_language":"en","subitem_text_value":"FUJIWARA, Toshinobu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"船上, 仁範"},{"creatorName":"フナカミ, ヨシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3299","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70449833","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=70449833"}]},{"creatorNames":[{"creatorName":"藤原, 俊伸"},{"creatorName":"フジワラ, トシノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43476","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K07929seika.pdf","filesize":[{"value":"247.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K07929seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23383/files/19K07929seika.pdf"},"version_id":"89998489-ccd3-4b55-8cbe-f0b7f35c3837"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"うつ","subitem_subject_scheme":"Other"},{"subitem_subject":"神経新生","subitem_subject_scheme":"Other"},{"subitem_subject":"RNA結合タンパク質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレス誘発うつ病の診断法確立に向けた基盤研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレス誘発うつ病の診断法確立に向けた基盤研究","subitem_title_language":"ja"},{"subitem_title":"Basic research for establishment of the diagnostics in stress-induced depression","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23383","relation_version_is_last":true,"title":["ストレス誘発うつ病の診断法確立に向けた基盤研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-12T06:09:22.026450+00:00"}