{"created":"2023-06-20T16:50:47.271490+00:00","id":23347,"links":{},"metadata":{"_buckets":{"deposit":"03ae5f69-561c-44d8-a118-e002c4fbdad8"},"_deposit":{"created_by":3,"id":"23347","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23347"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023347","sets":["14:2667:4819"]},"author_link":["43433"],"control_number":"23347","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K19967/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：照射細胞から放出された細胞間シグナル伝達物質を介して非照射細胞へ放射線影響を引き起こす「放射線誘発バイスタンダー効果」は、放射線抵抗性の腫瘍へ有害な影響を与える可能性が懸念されている。本研究では、軟骨肉腫を含む放射線抵抗性のがん細胞に対する良好な治療効果を得るための基盤的知見の取得に向けて、「細胞周期と連動したDNA損傷応答タンパク・DNA損傷応答キナーゼの挙動」に着目した。原因経路と細胞間情報伝達物質の関与を探ることにより、放射線誘発バイスタンダー効果の応答耐性メカニズムの一端を明らかにすることを目指した。\n研究成果の概要（英文）：“Bystander effects” are caused by radiation influences through intercellular communication to nearby non-irradiated cells, and may cause a decrease in the therapeutic effect on radiation-resistant tumors. This study focused on \"DNA damage/repair response linked to the cell cycle\" to obtain basic knowledge about radiation-resistant cancer cells such as chondrosarcoma and osteosarcoma. By narrowing down the causal pathway and the involvement of intercellular signals, this study aimed to clarify the resistance mechanism of radiation-induced bystander effects.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究; 研究期間：2020～2021; 課題番号：20K19967; 研究分野：放射線生物学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Ikeda, Hiroko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池田, 裕子"},{"creatorName":"イケダ, ヒロコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43433","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90806465","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=90806465"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"20K19967seika.pdf","filesize":[{"value":"533.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20K19967seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23347/files/20K19967seika.pdf"},"version_id":"9bb3644f-55a1-4b19-82ab-76f3a57795f8"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"バイスタンダー効果","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線抵抗性","subitem_subject_scheme":"Other"},{"subitem_subject":"DNA損傷・修復","subitem_subject_scheme":"Other"},{"subitem_subject":"染色体分裂異常","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"放射線抵抗性の軟骨肉腫細胞におけるDNA修復とバイスタンダー効果のメカニズム解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線抵抗性の軟骨肉腫細胞におけるDNA修復とバイスタンダー効果のメカニズム解明","subitem_title_language":"ja"},{"subitem_title":"Mechanism elucidation of bystander effects focusing on DNA repair in radioresistant chondrosarcoma cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23347","relation_version_is_last":true,"title":["放射線抵抗性の軟骨肉腫細胞におけるDNA修復とバイスタンダー効果のメカニズム解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T07:10:37.465968+00:00"}