{"created":"2023-06-20T16:50:47.203217+00:00","id":23346,"links":{},"metadata":{"_buckets":{"deposit":"d98f0082-4bd7-4e0a-8968-355403c8ef1e"},"_deposit":{"created_by":3,"id":"23346","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23346"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023346","sets":["14:2667:4819"]},"author_link":["33421"],"control_number":"23346","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K16343/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：トリプルネガティブ乳癌(TNBC；Triple negative breast cancer)の骨転移成立には、TNBCと骨髄間質細胞との相互作用が重要である。本研究では、TNBCと骨髄間質細胞との相互作用に関与する因子としてケモカイン受容体CXCR4を見出した。さらに、CXCR4を阻害することでTNBCの骨転移を抑制することを明らかにした。以上より、CXCR4が骨髄間質細胞と相互作用することで、TNBCの骨転移を亢進している可能性が示唆された。そして、CXCR4を阻害する薬剤がTNBCの骨転移を抑制する新たな治療薬となる可能性が期待される。\n研究成果の概要（英文）： Interactions between triple negative breast cancer (TNBC) and bone marrow stromal cells play the important role in bone metastasis. In this study, we clarified that CXCR4, chemokine receptor, involve the interactions between TNBC and bone marrow stromal cells. In addition, the inhibition of CXCR4 suppressed the bone metastasis of TNBC. Therefore, CXCR4 induce interactions between TNBC and bone marrow stromal cells, and promote bone metastasis of TNBC. Targeting CXCR4 may be valuable for developing therapeutic strategies against bone metastasis of TNBC.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究; 研究期間：2020～2021; 課題番号：20K16343; 研究分野：分子腫瘍学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Takeda, Tomoya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武田, 朋也"},{"creatorName":"タケダ, トモヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"20K16343seika.pdf","filesize":[{"value":"208.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20K16343seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23346/files/20K16343seika.pdf"},"version_id":"a46d5ac9-93e8-4623-8c82-15d3bafef397"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"トリプルネガティブ乳癌","subitem_subject_scheme":"Other"},{"subitem_subject":"骨転移","subitem_subject_scheme":"Other"},{"subitem_subject":"骨微小環境","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン受容体","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"トリプルネガティブ乳癌と骨髄間質細胞との相互作用を標的とした骨転移抑制剤の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"トリプルネガティブ乳癌と骨髄間質細胞との相互作用を標的とした骨転移抑制剤の開発","subitem_title_language":"ja"},{"subitem_title":"Interaction between triple negative breast cancer and bone marrow stromal cells promote bone metastasis.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23346","relation_version_is_last":true,"title":["トリプルネガティブ乳癌と骨髄間質細胞との相互作用を標的とした骨転移抑制剤の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T06:51:46.737849+00:00"}