{"created":"2023-06-20T16:50:45.193895+00:00","id":23315,"links":{},"metadata":{"_buckets":{"deposit":"a8653f25-24f1-4e23-9ac6-e4825a46b1c1"},"_deposit":{"created_by":3,"id":"23315","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23315"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023315","sets":["14:2667:4819"]},"author_link":["43519","43036","43520","43521","43522","43035","4057","43523"],"control_number":"23315","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K09285/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：複数のHER2標的薬について、肺癌・胃癌・乳癌細胞株を用いた感受性試験・獲得耐性の機序に関する検討を行い、その成果を複数の英文論文で報告した。さらに、新規HER阻害剤タルロキソチニブの感受性を確認し、HER2変異を導入したBa/F3細胞を用いて、耐性化に関与する新たな変異HER2 exon C805S変異を突き止め、英文論文報告した。また、肺扁平上皮癌患者におけるEGFR/HER2阻害剤アファチニブの有用性を検証したLUX-Lung8試験で同定された、アファチニブ感受性がある新たなHER2変異スペクトルをBa/F3細胞株に導入し、その病原性・薬剤感受性を検討し、英文論文報告した。\n研究成果の概要（英文）： We conducted sensitivity testing and investigated the mechanism of acquired resistance using lung, gastric, and breast cancer cell lines for several HER2-targeting agents, and reported the results in several English papers. In addition, we confirmed the sensitivity of a novel HER inhibitor, Tarloxotinib, and identified a new resistance-related mutation, HER2 exon C805S, involved in resistance using Ba/F3 cells transfected with HER2 mutation, which was reported in an English paper. A new afatinib-sensitive HER2 mutation spectrum identified in the LUX-Lung8 study, which evaluated the efficacy of the EGFR/HER2 inhibitor afatinib in patients with squamous cell lung cancer, was introduced into the Ba/F3 cell line and its pathogenicity and drug sensitivity were investigated and reported in an English paper.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K09285; 研究分野：呼吸器外科, 肺癌分子生物学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Soh, Junichi"},{"subitem_text_language":"en","subitem_text_value":"Tomida, Shuta"},{"subitem_text_language":"en","subitem_text_value":"Toyooka, Shinichi"},{"subitem_text_language":"en","subitem_text_value":"Yamamoto, Hiromasa"},{"subitem_text_language":"en","subitem_text_value":"Sakaguchi, Masakiyo"},{"subitem_text_language":"en","subitem_text_value":"Mitsudomi, Tetsuya"},{"subitem_text_language":"en","subitem_text_value":"Suda, Kenichi"},{"subitem_text_language":"en","subitem_text_value":"Suzawa, Ken"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"岡山大学大学病院; 准教授"},{"subitem_text_value":"岡山大学医歯薬学総合研究科; 教授"},{"subitem_text_value":"岡山大学大学病院; 講師"},{"subitem_text_value":"岡山大学医歯薬学総合研究科; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"岡山大学大学病院; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":""},{"subitem_text_value":""},{"subitem_text_value":""},{"subitem_text_value":""},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":""}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"宗, 淳一"},{"creatorName":"ソウ, ジュンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"冨田, 秀太"},{"creatorName":"トミダ, シュウタ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"豊岡, 伸一"},{"creatorName":"トヨオカ, シンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"山本, 寛斉"},{"creatorName":"ヤマモト, ヒロマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"阪口, 政清"},{"creatorName":"サカグチ, マサキヨ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"光冨, 徹哉"},{"creatorName":"ミツトミ, テツヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"須田, 健一"},{"creatorName":"スダ, ケンイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"諏澤, 憲"},{"creatorName":"スザワ, ケン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K09285seika.pdf","filesize":[{"value":"658.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K09285seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23315/files/19K09285seika.pdf"},"version_id":"cf073e91-37d8-4df6-9d0e-4770ff0396bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HER2","subitem_subject_scheme":"Other"},{"subitem_subject":"肺癌","subitem_subject_scheme":"Other"},{"subitem_subject":"薬剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"ERBB2","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"HER2異常肺癌に対する新しい治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"HER2異常肺癌に対する新しい治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of a new treatment strategy for HER2-alterated lung cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23315","relation_version_is_last":true,"title":["HER2異常肺癌に対する新しい治療法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T06:08:51.137847+00:00"}