{"created":"2023-06-20T16:50:45.062912+00:00","id":23313,"links":{},"metadata":{"_buckets":{"deposit":"52068f5d-e2d7-4f56-a25e-edddb9fce0f1"},"_deposit":{"created_by":3,"id":"23313","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23313"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023313","sets":["14:2667:4819"]},"author_link":["33529"],"control_number":"23313","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K08569/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：新規のウイルス性心筋炎モデルであるタイラーウイルス感染マウスを用いた本研究により、低侵襲性のバイオマーカーとなりうる分子を血液中および糞便中において同定した。血液中では、心筋トランスクリプトームデータとのパターンマッチングにより、Xaf1やOasl2などの自然免疫関連遺伝子が見出された。糞便中でも様々な腸内細菌量に変化が見られ、中枢神経系内の炎症性疾患における遺伝子発現変化との相関が見られた。特にCoprococcusはIgAとの相関が検出された。今後、タイラーウイルス感染モデルにおけるIgAおよび血小板の役割について、研究を展開していく。\n研究成果の概要（英文）： Using a novel model of viral myocarditis, Theiler's murine encephalomyelitis virus-infected mouse, our study identified the molecules in the blood and feces as minimally invasive biomarkers. In the blood, pattern matching with myocardial transcriptome data correlated with innate immunity-related genes, such as Xaf1 and Oasl2. In feces, we observed microbiota changes which correlated with changes in gene expression in inflammatory diseases in the central nervous system. In particular, Coprococcus was correlated with IgA gene expression. In the future, we will study the roles of IgA and platelets in Theiler's virus-infected mouse.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K08569; 研究分野：ウイルス学, 免疫学, バイオインフォマティクス; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Omura, Seiichi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"尾村, 誠一"},{"creatorName":"オムラ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K08569seika.pdf","filesize":[{"value":"460.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K08569seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23313/files/19K08569seika.pdf"},"version_id":"15e13526-a2bd-48df-a2f5-795228f0e18c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ウイルス性心筋炎","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌叢","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスクリプトーム","subitem_subject_scheme":"Other"},{"subitem_subject":"血小板","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫グロブリンA","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"バイオインフォマティクスによるウイルス性心筋炎予後判定・治療に寄与する分子の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"バイオインフォマティクスによるウイルス性心筋炎予後判定・治療に寄与する分子の同定","subitem_title_language":"ja"},{"subitem_title":"Bioinformatics analyses for identification of molecules which contribute to prognosis and treatment in viral myocarditis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23313","relation_version_is_last":true,"title":["バイオインフォマティクスによるウイルス性心筋炎予後判定・治療に寄与する分子の同定"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T06:00:18.734410+00:00"}