{"created":"2023-06-20T16:50:44.541939+00:00","id":23305,"links":{},"metadata":{"_buckets":{"deposit":"9cacb410-3260-4956-bbbb-8c522caf5f63"},"_deposit":{"created_by":3,"id":"23305","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23305"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023305","sets":["14:2667:4819"]},"author_link":["43508","30493"],"control_number":"23305","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07581/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究ではフレンドウイルス(FV)誘発赤白血病の発症維持機序をより明らかにすることを目的とし、マウスの正常骨髄赤血球前駆細胞とFV誘発白血病細胞とを解析した。まず、マウスのコロニー形成赤血球前駆細胞(CFU-E)を特徴づける複数のマーカー分子(細胞表面および細胞内)を同定した。その一方で、CFU-Eと比べてFV白血病細胞で発現が上昇している分子も複数同定した。それらFV白血病関連因子の解析を進め、白血病細胞の生存・増殖に関与する複数因子の同定に成功した。その成果は白血病病態生理の解明に資するのみならず、古典的はFV誘発赤白血病マウスモデルにより現代的な解釈を与えるものでもある。\n研究成果の概要（英文）： We here aimed to elucidate better the mechanisms for the onset and maintenance of leukemia. We analyzed murine bone marrow erythroid progenitors and Friend retrovirus (FV)-induced erythroleukemia cells. We first examined the phenotype of the colony-forming subset of erythroid progenitors (CFU-E) and identified several cell surface or intracellular markers. We further sought potential leukemia-associated factors overexpressed in FV-induced leukemia cells compared with normal CFU-E. Among those, we further identified several factors that support the survival and proliferation of leukemia cells. These results contribute to a better understanding of the pathogenesis of leukemia and help better interpret FV-infected mouse models.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K07581; 研究分野：ウイルス学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tsukamoto, Tetsuo"},{"subitem_text_language":"en","subitem_text_value":"Miyazawa, Masaaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"塚本, 徹雄"},{"creatorName":"ツカモト, テツオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43508","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80750223","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=80750223"}]},{"creatorNames":[{"creatorName":"宮澤, 正顯"},{"creatorName":"ミヤワザ, マサアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30493","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60167757","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=60167757"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K07581seika.pdf","filesize":[{"value":"172.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K07581seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23305/files/19K07581seika.pdf"},"version_id":"e2e34ffa-4553-4b61-b08c-8da83d9c5efb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"フレンド白血病ウイルス","subitem_subject_scheme":"Other"},{"subitem_subject":"赤白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"急性骨髄性白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"赤血球前駆細胞","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"フレンドウイルス感染マウスモデルを用いた白血病発症機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"フレンドウイルス感染マウスモデルを用いた白血病発症機構の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the mechanisms for leukemogenesis in Friend-virus infected mice","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23305","relation_version_is_last":true,"title":["フレンドウイルス感染マウスモデルを用いた白血病発症機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T05:18:43.693918+00:00"}