{"created":"2023-06-20T16:50:44.412036+00:00","id":23303,"links":{},"metadata":{"_buckets":{"deposit":"c4562f12-c891-4610-a115-bee173ffafa1"},"_deposit":{"created_by":3,"id":"23303","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23303"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023303","sets":["14:2667:4819"]},"author_link":["3167"],"control_number":"23303","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"13","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K07310/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究課題では、メカニカルストレスの変化によって骨格筋で発現が変動する体液性因子として、古典的Wnt-βカテニン経路の阻害因子であるDickkop (DKK)2に着目し、メカニカルストレスによって誘導される筋と骨の相互連関におけるDKK2の役割と作用機序を検討した。これまでの研究成果として、メカニカルストレス低下およびアンドロゲン欠乏によって筋でのDKK2発現が増加することが明らかになった。さらに、DKK2はマイオカインとして、メカニカルストレス低下およびアンドロゲン欠乏による骨量の減少に寄与することが示唆された。\n研究成果の概要（英文）： Myokines, humoral factors secreted from the skeletal muscles, have recently been getting attention as the key factors related to the interactions between muscle and bone. Dickkopf (DKK) 2 is known as an inhibitor of canonical Wnt/β-catenin signaling, and Wnt/β-catenin signaling is crucial for the maintenance of muscle and bone. The present study was performed to investigate the roles of DKK2 in the interactions between muscle and bone in response to mechanical stress in mice. In the present study, we showed that unloading and androgen deficiency enhance DKK2 expression and secretion in the muscles of mice. Dkk2 might be involved in unloading- and androgen deficiency-induced muscle wasting and osteopenia as a myokine linking muscle to bone.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K06175; 研究分野：生理学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kawao, Naoyuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河尾, 直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K07310seika.pdf","filesize":[{"value":"559.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K07310seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23303/files/19K07310seika.pdf"},"version_id":"e8469403-89ee-4842-9a79-e720ec437687"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"筋骨連関","subitem_subject_scheme":"Other"},{"subitem_subject":"DKK2","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"筋と骨のネットワーク機構におけるWnt-βカテニン経路阻害因子の役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"筋と骨のネットワーク機構におけるWnt-βカテニン経路阻害因子の役割の解明","subitem_title_language":"ja"},{"subitem_title":"Roles of Wnt/beta-catenin signaling inhibitors in interactions between muscle and bone","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23303","relation_version_is_last":true,"title":["筋と骨のネットワーク機構におけるWnt-βカテニン経路阻害因子の役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T05:11:19.596337+00:00"}