{"created":"2023-06-20T16:50:44.346963+00:00","id":23302,"links":{},"metadata":{"_buckets":{"deposit":"bbf9e2c0-c243-4d63-b1d7-3c9d0ddb2aab"},"_deposit":{"created_by":3,"id":"23302","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23302"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023302","sets":["14:2667:4819"]},"author_link":["33510","30484","33512","43496"],"control_number":"23302","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K06916/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、HPA axis 調節不全によるうつ病等の発症にmicroRNAが関与する分子機序を解明し、新規治療薬開発や予防措置への応用に向けた研究基盤の確立を目指すことを目的とした。本研究課題では、環境ストレス負荷マウスへの抑肝散投与によりGlucocorticoid 受容体 mRNA 転写後制御因子としてのmicroRNAを視床下部および脳梁領域それぞれで見出すことが出来た。\n研究成果の概要（英文）： It is well known that Glucocorticoid receptor signaling regulates the hypothalamic-pituitary-adrenal axis, and Glucocorticoid receptor expression level is associated with hypothalamic-pituitary-adrenal axis activity. A previous report has suggested that several microRNAs in the brain might regulate Glucocorticoid receptor protein levels. In this study, we aimed to elucidate the Glucocorticoid receptor regulation mechanism in the brain and evaluate the effects of Yokukansan on Glucocorticoid receptor regulation. This study found that Yokukansan regulates two different microRNAs as a post-transcriptional regulator of Glucocorticoid receptor mRNA in the hypothalamus and corpus callosum of environmentally stress-exposed mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2019～2021; 課題番号：19K06916; 研究分野：神経化学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tohyama, Masaya"},{"subitem_text_language":"en","subitem_text_value":"Miyata, Shingo"},{"subitem_text_language":"en","subitem_text_value":"Shimizu, Shoko"},{"subitem_text_language":"en","subitem_text_value":"Ishino, Yugo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学東洋医学研究所; 教授"},{"subitem_text_value":"近畿大学東洋医学研究所; 教授"},{"subitem_text_value":"近畿大学東洋医学研究所; 助教"},{"subitem_text_value":"近畿大学東洋医学研究所; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"遠山, 正彌"},{"creatorName":"トオヤマ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮田, 信吾"},{"creatorName":"ミヤタ, シンゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"清水, 尚子"},{"creatorName":"シミズ, ショウコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"石野, 雄吾"},{"creatorName":"イシノ, ユウゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K06916seika.pdf","filesize":[{"value":"174.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K06916seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23302/files/19K06916seika.pdf"},"version_id":"f57a9043-7fb4-4e2f-8c77-91b302e123be"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HPA axis","subitem_subject_scheme":"Other"},{"subitem_subject":"Glucocorticoid受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"視床下部","subitem_subject_scheme":"Other"},{"subitem_subject":"脳梁","subitem_subject_scheme":"Other"},{"subitem_subject":"microRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"抑肝散","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ストレス性精神症状改善に向けた抑肝散によるmicroRNA制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ストレス性精神症状改善に向けた抑肝散によるmicroRNA制御機構の解明","subitem_title_language":"ja"},{"subitem_title":"Molecular mechanisms of microRNA regulation by Yokukansan for improvement of stress-related psychiatric symptoms","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23302","relation_version_is_last":true,"title":["ストレス性精神症状改善に向けた抑肝散によるmicroRNA制御機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T05:07:40.563648+00:00"}