{"created":"2023-06-20T16:50:44.281105+00:00","id":23301,"links":{},"metadata":{"_buckets":{"deposit":"9fcae575-9902-4dde-8f2c-9a5253175e9d"},"_deposit":{"created_by":3,"id":"23301","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23301"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023301","sets":["14:2667:4819"]},"author_link":["4259","31732"],"control_number":"23301","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07651/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は、核医学治療（RI内用療法）において正常臓器や病巣の吸収線量を評価して治療手法の最適化を図ることを目的とした。核医学治療は基礎研究も臨床応用も目覚ましく発展している。このような背景のもとに、本研究では線量計算ソフトを導入して体内分布データに基づいて核医学治療における患者の線量計算手法を確立した。またラジウム-223治療を実施した去勢抵抗性前立腺癌骨転移のデータを蓄積し、個別化治療の開発に繋がる因子を解析した。今後の新しい核医学治療手法の開発においては体内分布データの取得手法を開発することと、それに基づいた線量評価を実施するための手法を構築していくことが重要であることを示した。\n研究成果の概要（英文）： The purpose of this study was to evaluate the absorbed dose in normal organs and lesions in Nuclear Medicine Therapy (Radionuclide Therapy) and to optimize the treatment method. Nuclear Medicine Therapy has made remarkable progress in both basic research and clinical application. Against this background, in this study, we introduced dose calculation software and established a patient dose calculation method in Nuclear Medicine Therapy based on biodistribution data. We also accumulated data on castration-resistant prostate cancer bone metastases treated with radium-223 and analyzed factors that lead to the development of personalized treatment. In the development of new Nuclear Medicine Therapy methods in the future, it is important to develop a method for acquiring biodistribution data and to construct a method for performing dose evaluation based on it.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2018～2021; 課題番号：18K07651; 研究分野：腫瘍核医学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Hosono, Makoto"},{"subitem_text_language":"en","subitem_text_value":"Wakabayashi, Genichiro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学原子力研究所; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細野, 眞"},{"creatorName":"ホソノ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"若林, 源一郎"},{"creatorName":"ワカバヤシ, ゲンイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"18K07651seika.pdf","filesize":[{"value":"263.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K07651seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23301/files/18K07651seika.pdf"},"version_id":"1efec5e5-99a2-416f-a58f-007c31643e2d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"核医学治療","subitem_subject_scheme":"Other"},{"subitem_subject":"RI内用療法","subitem_subject_scheme":"Other"},{"subitem_subject":"線量評価","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新規核種のRI内用療法における線量評価と個別化治療の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新規核種のRI内用療法における線量評価と個別化治療の開発","subitem_title_language":"ja"},{"subitem_title":"Development of Dosimetry and Personalized Treatment in Radionuclide Therapy with Novel Nuclides","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23301","relation_version_is_last":true,"title":["新規核種のRI内用療法における線量評価と個別化治療の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T05:02:47.583354+00:00"}