{"created":"2023-06-20T16:50:44.088389+00:00","id":23297,"links":{},"metadata":{"_buckets":{"deposit":"df504050-2761-44e7-802f-826883df0787"},"_deposit":{"created_by":3,"id":"23297","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23297"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023297","sets":["14:2667:4819"]},"author_link":["4274","4167","30473","3301"],"control_number":"23297","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19H03794/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：我々はペプチドワクチン開発に着手し、5分子に対するワクチンを開発し、一部は特許申請を行い、2021年度に2つの特許（特許第6900610号、特許第6918333号）を取得し得た。今回の研究目的はペプチドワクチンと各IO-drugとの併用による抗腫瘍免疫増強効果について、実際の臨床検体を用いて検討することである。COVID-19禍の影響を受け十分なサンプル収集ができなかったが、腎癌担癌患者でIO-drug非投与患者、投与患者からのサンプルを用いてIO治療によるワクチン効果増強についてパイロット研究を行い検討してきた。なお、一連のCTL誘導に関する研究結果などについては特許の関係上公表していない。\n研究成果の概要（英文）： We have been working on the development of new MHC Class-I restricted peptide vaccines for five independent therapeutic targets (CA9, VEGFR1, EPOR, PDL1, HIF1) and our studies have successfully resulted in two Japanese patents (#6900610, #6918333) in 2021. We are currently investigating immunological evaluations of our peptide vaccines with immune check point therapies using PBMCs from advanced RCC patients receiving IO-drugs. Most of the data such as ability of specific CTL induction are not reported in public due to patent.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B); 研究期間：2019～2021; 課題番号：19H03794; 研究分野：泌尿器腫瘍学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Uemura, Hirotsugu"},{"subitem_text_language":"en","subitem_text_value":"De Velasco, Marco"},{"subitem_text_language":"en","subitem_text_value":"Harada, Mamoru"},{"subitem_text_language":"en","subitem_text_value":"Minami, Takafumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"島根大学学術研究院医学・看護学系; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":""},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"植村, 天受"},{"creatorName":"ウエムラ, ヒロツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"デベラスコ, マルコ"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"原田, 守"},{"creatorName":"ハラダ, マモル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"南, 高文"},{"creatorName":"ミナミ, タカフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19H03794seika.pdf","filesize":[{"value":"106.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19H03794seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23297/files/19H03794seika.pdf"},"version_id":"4ac7d8b9-4a6e-46d2-959f-3dd024fc73fb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腎細胞癌","subitem_subject_scheme":"Other"},{"subitem_subject":"ペプチドワクチン","subitem_subject_scheme":"Other"},{"subitem_subject":"複合免疫療法","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"腎細胞癌に対するマルチペプチド癌ワクチンの開発、複合免疫療法としての有用性の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"腎細胞癌に対するマルチペプチド癌ワクチンの開発、複合免疫療法としての有用性の検討","subitem_title_language":"ja"},{"subitem_title":"Development of combination immunotherapy with peptide vaccines for renal cell carcinoma.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23297","relation_version_is_last":true,"title":["腎細胞癌に対するマルチペプチド癌ワクチンの開発、複合免疫療法としての有用性の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T04:36:40.223397+00:00"}