{"created":"2023-06-20T16:50:43.913077+00:00","id":23293,"links":{},"metadata":{"_buckets":{"deposit":"f2e2fff0-7d29-4d38-b020-d0962dbb661e"},"_deposit":{"created_by":3,"id":"23293","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23293"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023293","sets":["14:2667:4819"]},"author_link":["43504"],"control_number":"23293","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K17545/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：内分泌臓器を標的とする免疫関連有害事象（irAE）の頻度は、甲状腺、下垂体、膵β細胞（1型糖尿病）の順で高頻度であった。甲状腺irAEにおける甲状腺自己抗体陽性率は62.5％であった。irAEによる１型糖尿病の膵島関連自己抗体陽性率は33.3％であり、全例でインスリン依存状態となった。下垂体irAEでは、ACTH単独欠損が54.8％と最多であった。HLA疾患感受性ハプロタイプについて、甲状腺irAEは自己免疫性甲状腺疾患と、irAEによる１型糖尿病は自然発症1型糖尿病とそれぞれ同程度に保有しており、irAEは標的臓器を同じくする自然発症自己免疫疾患と遺伝的に類似性を有する可能性が示唆された。\n研究成果の概要（英文）： The frequency of immune-related adverse events (irAEs) specific to endocrine organs was highest in the order of thyroid gland, pituitary gland, and pancreatic β-cells (type 1 diabetes). The positive rate of thyroid autoantibodies in thyroid-specific irAE was 62.5%; the positive rate of pancreatic islet-related autoantibodies for irAE-induced type 1 diabetes was 33.3%, and all patients with irAE-induced type 1 diabetes were insulin-dependent. The highest frequency of pituitary-specific irAE was ACTH alone deficiency (54.8%). Analysis of HLA haplotypes that confer disease susceptibility to organ-specific autoimmune diseases showed that the haplotype frequency in thyroid-specific irAE and irAE-induced type 1 diabetes was comparable to that in spontaneous autoimmune thyroid disease and spontaneous type 1 diabetes, respectively. Endocrine organ-specific irAE was suggested to be genetically similar in HLA haplotypes to spontaneous autoimmune diseases for common target organs.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究; 研究期間：2020～2021; 課題番号：20K17545; 研究分野：内分泌代謝; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Taketomo, Yasunori"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"武友, 保憲"},{"creatorName":"タケトモ, ヤスノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43504","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20580591","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=20580591"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"20K17545seika.pdf","filesize":[{"value":"183.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20K17545seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23293/files/20K17545seika.pdf"},"version_id":"79325c2c-136c-4714-9b78-853fc1ae2a12"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"免疫関連有害事象","subitem_subject_scheme":"Other"},{"subitem_subject":"甲状腺機能障害","subitem_subject_scheme":"Other"},{"subitem_subject":"下垂体機能障害","subitem_subject_scheme":"Other"},{"subitem_subject":"1型糖尿病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫チェックポイント阻害による特異的内分泌細胞破壊の病態解明と予知","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫チェックポイント阻害による特異的内分泌細胞破壊の病態解明と予知","subitem_title_language":"ja"},{"subitem_title":"Elucidation and prediction of specific endocrine cell destruction by immune checkpoint inhibition","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23293","relation_version_is_last":true,"title":["免疫チェックポイント阻害による特異的内分泌細胞破壊の病態解明と予知"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T02:08:30.593194+00:00"}