{"created":"2023-06-20T16:50:43.738308+00:00","id":23289,"links":{},"metadata":{"_buckets":{"deposit":"52f05877-25c9-4d52-980e-5aa286d5e808"},"_deposit":{"created_by":3,"id":"23289","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23289"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023289","sets":["14:2667:4819"]},"author_link":["43501"],"control_number":"23289","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18824/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：まず、ChR2(光感受性非選択的陽イオンチャネル)が遺伝子改変マウスの蝸牛神経と坐骨神経の髄鞘に発現しているかを免疫組織化学実験により確かめた。電子顕微鏡を用いた詳細な解析(paranodeやjuxtaparanodeへの発現解析)までは行えなかったが、標的細胞への発現までは確認できた。中枢神経系の髄鞘の脱分極による神経刺激作用が報告されていることから、同様に末梢神経系でも生じ、それが神経再生の助長につながる可能性もあるという仮説をたて、in vivo実験を施行した。蝸牛神経の電気刺激応答は光刺激により、軽度ではあるが潜時の短縮が認められた。坐骨神経に対する同様の実験は現在検討中である。\n研究成果の概要（英文）： First, the expression of ChR2 (light-gated non-selective cation channel) in the cochlear and sciatic glial cells of transgenic mice was examined with immunohistochemistry IHC). Although the detailed analysis identifying the precise expression sites with electron microscopy was not performed, ChR2-expressing targeted cells were confirmed using IHC. Based on the previous reports, we hypothesized depolarization of the glia cells could cause stimulation of the peripheral nerve, leading possibly to facilitation of nerve regeneration. In in-vivo experiments, the latency of the electrical response in the cochlear nerves became slightly shortened. The same experiments has been ongoing in the sciatic nerve.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究; 研究期間：2019～2021; 課題番号：19K18824; 研究分野：inner ear; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Sato, Mitsuo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 医学部講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"佐藤, 満雄"},{"creatorName":"サトウ, ミツオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K18824seika.pdf","filesize":[{"value":"184.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K18824seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23289/files/19K18824seika.pdf"},"version_id":"b179d636-ba42-4f1d-96ca-c830b1374518"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"inner ear","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"peripheral nervous","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"electrophysiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"蝸牛神経と坐骨神経のシュワン細胞の膜電位変化がそれぞれの神経に与える影響の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"蝸牛神経と坐骨神経のシュワン細胞の膜電位変化がそれぞれの神経に与える影響の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of the effect of membrane potential change in the schwann cell of the cochlear and sciatic nerve on each of nerves","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23289","relation_version_is_last":true,"title":["蝸牛神経と坐骨神経のシュワン細胞の膜電位変化がそれぞれの神経に与える影響の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T01:52:05.970347+00:00"}