{"created":"2023-06-20T16:50:43.325919+00:00","id":23282,"links":{},"metadata":{"_buckets":{"deposit":"640d5dc8-d402-4f4b-8b6c-ed519e11e73c"},"_deposit":{"created_by":3,"id":"23282","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23282"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023282","sets":["14:2667:4819"]},"author_link":["43496"],"control_number":"23282","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K16268/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：(1)タンパク質のアルギニンメチル化酵素の一つであるCARM1が発達期のオリゴデンドロサイト、特に髄鞘形成期をピークに発達期に高く発現することを見出した。(2)CARM1の機能抑制によってオリゴデンドロサイトの分裂や分化が低下することを見出した。それに伴ってCARM1の機能抑制によってオリゴデンドロサイトで機能する遺伝子の発現が低下していることを見出した。(3)CARM1の機能抑制によってオリゴデンドロサイトの分化抑制および神経軸索への髄鞘形成が顕著に低下することが明らかとなった。\n研究成果の概要（英文）： Protein arginine methylation has been recognized as one of key posttranslational modifications, which is mediated by protein arginine methyltransferases (PRMTs). Although arginine-methylated proteins are highly expressed in the brain, the expression and function of PRMTs have remained largely unknown. In this study, we revealed that CARM1, one of PRMTs, regulates proliferation, differentiation and myelination of oligodendrocytes during the early brain development.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究; 研究期間：2019～2021; 課題番号：19K16268; 研究分野：脳発達; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Ishino, Yugo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学東洋医学研究所; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石野, 雄吾"},{"creatorName":"イシノ, ユウゴ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43496","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80625088","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=80625088"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"19K16268seika.pdf","filesize":[{"value":"75.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K16268seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23282/files/19K16268seika.pdf"},"version_id":"1d0c1a79-f2e9-4d79-8e81-694700661274"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オリゴデンドロサイト","subitem_subject_scheme":"Other"},{"subitem_subject":"アルギニンメチル化","subitem_subject_scheme":"Other"},{"subitem_subject":"PRMTs","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"うつ様病態時においてオリゴデンドロサイト機能低下を惹起する新規分子機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"うつ様病態時においてオリゴデンドロサイト機能低下を惹起する新規分子機構の解明","subitem_title_language":"ja"},{"subitem_title":"Towards understanding of novel molecular mechanisms regulating oligodendrocyte differentiation and myelination","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23282","relation_version_is_last":true,"title":["うつ様病態時においてオリゴデンドロサイト機能低下を惹起する新規分子機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T00:46:23.384262+00:00"}