{"created":"2023-06-20T16:50:43.195310+00:00","id":23280,"links":{},"metadata":{"_buckets":{"deposit":"35acb669-5d6d-498c-bd2b-22e3faf3c6ee"},"_deposit":{"created_by":3,"id":"23280","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23280"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023280","sets":["14:2667:4819"]},"author_link":["43494"],"control_number":"23280","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20K23012/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、高い骨再生能を持つことが報告される間葉系幹細胞スフェロイドの骨修復・再生メカニズムの解明を目的に研究を行った。脂肪組織由来間葉系幹細胞（ADSCs）をスフェロイド化し、健常マウスおよびストレプトゾトシン誘発性糖尿病モデルマウスの大腿骨欠損部に移植した。しかし、ADSCsのスフェロイド化による有意な骨修復・再生効果はみられなかった。また、足場素材、移植細胞数、スフェロイドサイズの変更によっても、骨修復・再生効果に改善はみられなかった。以上の結果より、ADSCsスフェロイドでは予想された骨修復・再生の促進効果がみられなかったため、骨修復・再生促進メカニズムの解明に至らなかった。\n研究成果の概要（英文）： In this study, I challenged to elucidate the bone regeneration mechanism of mesenchymal stem cell spheroids, which have been reported to show high bone regeneration capacity. Adipose tissue-derived mesenchymal stem cells (ADSCs) spheroids were fabricated and transplanted into femoral bone defects of healthy mice and streptozotocin-induced diabetic model mice. However, ADSCs spheroids showed no significant bone regeneration effect. In addition, the bone regeneration effect of ADSCs spheroids was not improved by changing the scaffold material, the number of transplanted cells, or the spheroid size. Therefore, ADSCs spheroids did not show the expected bone regeneration effect, and so the mechanism of bone regeneration promotion of ADSCs spheroids could not be elucidated.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：研究活動スタート支援; 研究期間：2020～2021; 課題番号：20K23012; 研究分野：骨代謝, DDS, 組織工学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Mizukami, Yuya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"水上, 優哉"},{"creatorName":"ミズカミ, ユウヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"20K23012seika.pdf","filesize":[{"value":"321.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"20K23012seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23280/files/20K23012seika.pdf"},"version_id":"ca65797e-be17-4511-a26a-b20d76764070"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"骨再生","subitem_subject_scheme":"Other"},{"subitem_subject":"間葉系幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"スフェロイド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"高い骨再生能を持つ間葉系幹細胞スフェロイドの骨修復・再生メカニズムの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"高い骨再生能を持つ間葉系幹細胞スフェロイドの骨修復・再生メカニズムの解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of bone regenerative mechanism after mesenchymal stem cell spheroid transplantation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23280","relation_version_is_last":true,"title":["高い骨再生能を持つ間葉系幹細胞スフェロイドの骨修復・再生メカニズムの解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T00:37:42.594987+00:00"}