{"created":"2023-06-20T16:50:43.130016+00:00","id":23279,"links":{},"metadata":{"_buckets":{"deposit":"4a8271b9-bf43-425a-8d33-a461e95ebb7f"},"_deposit":{"created_by":3,"id":"23279","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23279"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023279","sets":["14:2667:4819"]},"author_link":["3271","31880","30538","3999","43490","31963","43491","43492","43493"],"control_number":"23279","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"51","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2021)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PLANNED-17H06404/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：炎症性腸疾患における宿主・微生物間の相互作用を検討し、以下の成果を得た。腸内細菌叢によるリボヌクレオプロテイン複合体生合成、サイトカインシグナル活性化が、大腸粘膜のDNA修復やIFN-γシグナル等に影響を与え、免疫チェックポイント阻害薬の反応性、免疫関連大腸炎に関連する。免疫チェックポイント阻害薬による免疫関連大腸炎は、潰瘍性大腸炎との間に腸組織と微生物組成に機能的な類似性をみとめるが、Bacteroides種の減少により、脂肪酸輸送システムが両病態で亢進し、免疫細胞が再構築される。多発性硬化症に腸内細菌叢が関与し、クルクミンモノグルクロニドにより組織学的、臨床的な変調をきたす。\n研究成果の概要（英文）： Host-microbe interactions in inflammatory bowel disease were investigated. Activation of ribonucleoprotein complex biosynthesis and cytokine signaling pathway mediated by the gut microbiota affected DNA repair, IFN-γ signaling, etc. in the colonic mucosa and was associated with response to immune checkpoint inhibitors and immune-related colitis. Immune checkpoint inhibitor-induced immune-associated colitis showed functional similarities in gut tissue and microbial composition with ulcerative colitis, but decreased Bacteroides species resulted in an enhanced fatty acid transport system and immune cell reorganization in both diseases. The gut microbiota is involved in pathogenesis of multiple sclerosis and curcumin monoglucuronide modulated microbiota and the pathogenesis histologically.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：新学術領域研究（研究領域提案型）; 研究期間：2017～2021; 課題番号：17H06404; 研究分野：医学; 科研費の分化・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Nishio, Kazuto"},{"subitem_text_language":"en","subitem_text_value":"Tsunoda, Ikuo"},{"subitem_text_language":"en","subitem_text_value":"Okada, Hitoshi"},{"subitem_text_language":"en","subitem_text_value":"Sakai, Kazuko"},{"subitem_text_language":"en","subitem_text_value":"Ueshima, kazuomi"},{"subitem_text_language":"en","subitem_text_value":"Sakurai, Toshiharu"},{"subitem_text_language":"en","subitem_text_value":"Omura, Seiichi"},{"subitem_text_language":"en","subitem_text_value":"Takahama, Takayuki"},{"subitem_text_language":"en","subitem_text_value":"Amano, Hisayuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"西尾, 和人"},{"creatorName":"ニシオ, カズト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"角田, 郁生"},{"creatorName":"ツノダ, イクオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岡田, 斉"},{"creatorName":"オカダ, ヒトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"坂井, 和子"},{"creatorName":"サカイ, カズコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"上嶋, 一臣"},{"creatorName":"ウエシマ, カズオミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"櫻井, 俊治"},{"creatorName":"サクライ, トシハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"尾村, 誠一"},{"creatorName":"オムラ, セイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"高濱, 隆幸"},{"creatorName":"タカハマ, タカユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"天野, 恭志"},{"creatorName":"アマノ, ヒサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-12-05"}],"displaytype":"detail","filename":"17H06404seika.pdf","filesize":[{"value":"508.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17H06404seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/23279/files/17H06404seika.pdf"},"version_id":"efc3f87b-79b0-4bf8-b21d-520b963af7bf"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"腸内細菌","subitem_subject_scheme":"Other"},{"subitem_subject":"炎症性腸疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"中枢神経炎","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫関連有害事象","subitem_subject_scheme":"Other"},{"subitem_subject":"エンリッチメント解析","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ヒト-細菌叢間 化学コミュニケーションの理解と炎症性腸疾患・がん・がん免疫","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ヒト-細菌叢間 化学コミュニケーションの理解と炎症性腸疾患・がん・がん免疫","subitem_title_language":"ja"},{"subitem_title":"Chemical communication between human and microflora in inflammatory bowel disease, carcinogenesis, and cancer immunity","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4819"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2022-12-05"},"publish_date":"2022-12-05","publish_status":"0","recid":"23279","relation_version_is_last":true,"title":["ヒト-細菌叢間 化学コミュニケーションの理解と炎症性腸疾患・がん・がん免疫"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T00:30:42.776846+00:00"}