{"created":"2023-06-20T16:50:33.189555+00:00","id":23126,"links":{},"metadata":{"_buckets":{"deposit":"29d8568e-b145-4777-bc90-3d7aa2d7f86d"},"_deposit":{"created_by":3,"id":"23126","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23126"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023126","sets":["14:923:1477:4811"]},"author_link":["40834"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-12-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"213","bibliographicPageStart":"203","bibliographicVolumeNumber":"31","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] (目的)これまで，われわれは，骨・軟骨組織の再生誘導を行う際，細胞の足場となる生分解性ポリマーとしてpoly (L-lactide-ε-caprolactone)(P(LA-CL))を用いてきた．しかし，P(LA-CL)は，力学的強度が不足していた．そこで本研究では，生分解性ポリマーP(LA-CL)に，高い力学的強度と骨伝導能を有するセラミックス粒子(Hydroxyapatite，β-tricalcium phosphate)を付加して，新しい骨誘導型の生分解性ポリマーを開発した．さらに，この新型ポリマーをヒト指骨モデルに導入して，指骨の再生能と有用性について比較検討した．(方法)仔ウシ橈骨より採取した骨膜を，ヒト指骨形状を有する3次元生分解性ポリマーと組み合わせて複合体を作成し，ヌードマウスの背部皮下に移植した．移植後，10週，20週にて標本を取り出し，(1)肉眼的観察，(2)単純X線写真による検索，(3)組織学的検索，(4)メカニカルテストを行った．実験群として，(1)P(LA-CL)群 (2)HA-P(LA-CL) (3)β-TCP-P(LA-CL)の3群を設定した．(結果およびまとめ)肉眼的所見では，すべての群において3次元構造が維持されていた．しかし，単純X線写真による所見および組織学的所見では，P(LA-CL)群に比較して，HA-P(LA-CL)群およびβ-TCP-P(LA-CL)群において，著明な骨形成が認められた．また，メカニカルテストでは，P(LA-CL)群に比較してHA-P(LA-CL)群およびβ-TCP-P(LA-CL)群において，有意な力学的強度の増加が認められた．これらの結果より，セラミックス粒子を含有した新たな生分解性ポリマーを足場とすることにより，早期の骨再生および3次元構造の維持が可能となることが示唆された．","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部形成外科学教室"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"和田, 仁孝"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-21"}],"displaytype":"detail","filename":"AN00063584-20061225-0203.pdf","filesize":[{"value":"1.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20061225-0203.pdf","url":"https://kindai.repo.nii.ac.jp/record/23126/files/AN00063584-20061225-0203.pdf"},"version_id":"e90c7f77-2ac6-4d08-ae9f-7cf56a2eb21c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Tissue Engneering","subitem_subject_scheme":"Other"},{"subitem_subject":"Poly(L-lactide-ε-caprolactone)","subitem_subject_scheme":"Other"},{"subitem_subject":"Hydroxyapatite","subitem_subject_scheme":"Other"},{"subitem_subject":"β-tricalcium phosphate","subitem_subject_scheme":"Other"},{"subitem_subject":"骨再生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉新たな骨誘導型生分解ポリマーを用いた指骨の再生誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉新たな骨誘導型生分解ポリマーを用いた指骨の再生誘導"}]},"item_type_id":"2","owner":"3","path":["4811"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-21"},"publish_date":"2022-09-21","publish_status":"0","recid":"23126","relation_version_is_last":true,"title":["〈原著〉新たな骨誘導型生分解ポリマーを用いた指骨の再生誘導"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T20:04:03.804647+00:00"}