{"created":"2023-06-20T16:50:29.733359+00:00","id":23063,"links":{},"metadata":{"_buckets":{"deposit":"9fabb1e9-578e-4761-afa8-785f236c2b45"},"_deposit":{"created_by":3,"id":"23063","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"23063"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00023063","sets":["14:923:1477:4808"]},"author_link":["41932"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-09-25","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"158","bibliographicPageStart":"149","bibliographicVolumeNumber":"32","bibliographic_titles":[{"bibliographic_title":"近畿大学医学雑誌"},{"bibliographic_title":"Medical Journal of Kinki University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[抄録] 近年，骨誘導能をもつサイトカインを用いた骨再建法が注目されている．しかし，サイトカインを単独で生体内に注入しても，早期に拡散・吸収され，骨形成促進作用は制限される．そこで本研究では，骨形成促進作用を有するサイトカインであるBone morphogenetic protein-2(以下，BMP-2)をゼラチンハイドロゲルにより徐放化することを試みた(実験1)．さらに，生分解性ポリマーと複合化させ，骨欠損部における骨再生の有用性について検討した(実験2)．実験1では，^<125>Iによって標識したBMP-2溶液，ゼラチンハイドロゲル単体およびBMP-2含浸ゼラチンハイドロゲルをそれぞれヌードマウス皮下に投与し放射能活性残存率を測定した．その結果，ゼラチンハイドロゲルの経時的な分解によりBMP-2が徐放されていることが示唆された．実験2では，イヌ眼窩床骨折モデルを作製し，BMP-2含浸ゼラチンハイドロゲル・生分解性ポリマー複合体を眼窩骨欠損部へ移植した．移植後，骨欠損部について，単純X線写真による検索，組織学的検索およびマイクロCTを用いた骨構造解析を行った．その結果，BMP-2含浸ゼラチンハイドロゲル・生分解性ポリマー複合体において新生骨組織が再生誘導された．さらにこの新生骨組織は，正常骨組織に近似した骨梁の再構築を示した．","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"本文データはCiNiiから複製したものである。","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学医学会"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03858367","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部形成外科学教室"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"望月, 祐一"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-09-14"}],"displaytype":"detail","filename":"AN00063584-20070925-0149.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AN00063584-20070925-0149.pdf","url":"https://kindai.repo.nii.ac.jp/record/23063/files/AN00063584-20070925-0149.pdf"},"version_id":"5e40f40b-1e3b-4dde-abcd-833e24beba0d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ゼラチンハイドロゲル","subitem_subject_scheme":"Other"},{"subitem_subject":"生分解性ポリマー","subitem_subject_scheme":"Other"},{"subitem_subject":"BMP-2","subitem_subject_scheme":"Other"},{"subitem_subject":"眼窩床骨折","subitem_subject_scheme":"Other"},{"subitem_subject":"骨構造解析","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈原著〉BMP-2含浸徐放ゼラチンハイドロゲルシートによる骨再生とイヌ眼窩床骨折モデルへの応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈原著〉BMP-2含浸徐放ゼラチンハイドロゲルシートによる骨再生とイヌ眼窩床骨折モデルへの応用"}]},"item_type_id":"2","owner":"3","path":["4808"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-09-14"},"publish_date":"2022-09-14","publish_status":"0","recid":"23063","relation_version_is_last":true,"title":["〈原著〉BMP-2含浸徐放ゼラチンハイドロゲルシートによる骨再生とイヌ眼窩床骨折モデルへの応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:59:10.591907+00:00"}