{"created":"2023-06-20T16:50:15.705219+00:00","id":22756,"links":{},"metadata":{"_buckets":{"deposit":"fc3657bb-46d0-441e-92db-7397aee1501b"},"_deposit":{"created_by":3,"id":"22756","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22756"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022756","sets":["14:923:2219:4782"]},"author_link":["39886","39885","39884"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"27","bibliographicPageEnd":"22","bibliographicPageStart":"15","bibliographic_titles":[{"bibliographic_title":"近畿大学先端技術総合研究所紀要"},{"bibliographic_title":"Memoirs of Institute of Advanced Technology, Kindai University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[要旨]様々ながん医薬品の多くは細胞内シグナル伝達経路タンパク質を競争的に阻害するが、抵抗性獲得の問題があり従来とは異なるアプローチによるがん薬剤創薬が求められている。我々はNMR と計算機科学を組み合わせた独自の方法でその標的分子の揺らぎを制御するアロステリック制御薬の探索法確立を目標として共同研究を進めている。モデル標的分子として、がん細胞が示す共通の代謝状態（がん代謝）に関連するタンパク質の一つであるENTPD5 の分子動力学シミュレーション計算とその基礎的なデータ解析を実施したのでその内容を報告する。[Abstract] Many cancer drugs competitively inhibit intracellular signaling pathway proteins, but due to the problem of drug resistance, there is a need for a different approach to cancer drug discovery. We are collaborating to establish a method to search for allosteric regulators that control the fluctuations of their target molecules using our method that combines NMR and computer science. As a model target molecule, we have performed molecular dynamics simulation calculations and basic data analysis of ENTPD5, which is one of the proteins related to the common metabolic state shown by cancer cells (cancer metabolism).","subitem_description_type":"Abstract"}]},"item_2_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Research Notes","subitem_description_type":"Other"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学先端技術総合研究所"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468693","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shiraki, Takuma"},{"subitem_text_language":"en","subitem_text_value":"Sakurai, Kazumasa"},{"subitem_text_language":"en","subitem_text_value":"Yonezawa, Yasushige"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学生物理工学部食品安全工学科"},{"subitem_text_value":"近畿大学先端技術総合研究所高圧力蛋白質研究センター"},{"subitem_text_value":"近畿大学先端技術総合研究所高圧力蛋白質研究センター"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Science and Technology on Food Safety, Faculty of Biology-Oriented Science and Technology, Kindai University"},{"subitem_text_value":"High Pressure Protein Research Center, Institute of Advanced Technology, Kindai University"},{"subitem_text_value":"High Pressure Protein Research Center, Institute of Advanced Technology, Kindai University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白木, 琢磨"},{"creatorName":"シラキ, タクマ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"櫻井, 一正"},{"creatorName":"サクライ, カズマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"米澤, 康滋"},{"creatorName":"ヨネザワ, ヤスシゲ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-19"}],"displaytype":"detail","filename":"AA11574630-20220331-0015.pdf","filesize":[{"value":"937.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA11574630-20220331-0015.pdf","url":"https://kindai.repo.nii.ac.jp/record/22756/files/AA11574630-20220331-0015.pdf"},"version_id":"6d16165d-e3c0-44f7-a2de-7b654744f188"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"タンパク質","subitem_subject_scheme":"Other"},{"subitem_subject":"分子動力学シミュレーション","subitem_subject_scheme":"Other"},{"subitem_subject":"アロステリック創薬","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"protein","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"molecular dynamics simulation","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"allosteric drug discovery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"cancer","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"―研究ノート―アロステリック制御薬剤探索に向けた高圧力蛋白質研究センターの取り組み","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"―研究ノート―アロステリック制御薬剤探索に向けた高圧力蛋白質研究センターの取り組み"},{"subitem_title":"-Research Note- High Pressure Protein Research Center's Efforts to Explore Allosteric Regulators","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["4782"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-05-19"},"publish_date":"2022-05-19","publish_status":"0","recid":"22756","relation_version_is_last":true,"title":["―研究ノート―アロステリック制御薬剤探索に向けた高圧力蛋白質研究センターの取り組み"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T20:52:02.478934+00:00"}