{"created":"2023-06-20T16:49:59.936829+00:00","id":22387,"links":{},"metadata":{"_buckets":{"deposit":"1dd9c8bc-d84e-45d4-885f-15c043ff1d0c"},"_deposit":{"created_by":3,"id":"22387","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22387"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022387","sets":["14:2667:4710"]},"author_link":["43088"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06022/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06022/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：アルギニル化はアルギニン転移酵素（ATE1）によってタンパク質にアルギニンが結合する翻訳後修飾であり、発生に必須であるが、配偶子形成とのかかわりは明らかではない。本研究では、それを明らかにするために、マウス卵母細胞におけるアルギニル化タンパク質の解析をおこなった。第二減数分裂中期（MII）期の卵母細胞において、アルギニル化β-アクチンは紡錘体に強く局在した。卵核胞期（GV期）およびMii期の卵母細胞において、雌の生殖能力あるいは初期胚発生において重要となるタンパク質がアルギニル化を受けていた。これらの結果は、アルギニル化の生殖・発生へのかかわりの解明に向けての新規かつ重要な知見である。研究成果の概要（英文）：Arginylation is a posttranslational modification mediated by arginyltransferase (ATE1). Arginylation is essential for the development, however, its involvement in gametogenesis is still unknown. This study was conducted to elucidate the involvement of arginylation in the female gametogenesis. Arginylated beta-actin localized to the meiotic spindle in the oocytes at metaphase II stage. We identified arginylated proteins in the oocytes at germinal vesicle and metaphase II stages, and some of them are important for female fertility or preimplantation development. These novel and important results are significant steps to elucidate the involvement of arginylatiion in female fertility and development.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K06022;   研究分野：細胞生物学、発生生物学、生殖生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Kurosaka, Satoshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学先端技術総合研究所; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"黒坂, 哲"},{"creatorName":"クロサカ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43088","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30625356","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-03-07"}],"displaytype":"detail","filename":"18K06022seika.pdf","filesize":[{"value":"225.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K06022seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22387/files/18K06022seika.pdf"},"version_id":"3d38d0a7-c3d7-4950-aa38-19b2e93e8e6b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"アルギニル化","subitem_subject_scheme":"Other"},{"subitem_subject":"雌性配偶子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"雌性配偶子形成におけるアルギニル化の機能の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"雌性配偶子形成におけるアルギニル化の機能の解明"},{"subitem_title":"Arginylation in female gametogenesis.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-03-07"},"publish_date":"2022-03-07","publish_status":"0","recid":"22387","relation_version_is_last":true,"title":["雌性配偶子形成におけるアルギニル化の機能の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:46:38.298096+00:00"}