| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-12-02 |
| タイトル |
|
|
タイトル |
<Originals> Effect of antifibrotic agents on survival in idiopathic pulmonary fibrosis patients according to forced vital capacity: a real-world retrospective cohort study in Japan |
|
言語 |
en |
| 著者 |
Saeki, Sho
Nishiyama, Osamu
Yamazaki, Ryo
Yoshikawa, Kazuya
Shirahase, Ken
Gose, Kyuya
Oomori, Takashi
Nishikawa, Yusaku
Sano, Akiko
Sano, Hiroyuki
Iwanaga, Takashi
Matsumoto, Hisako
Tohda, Yuji
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
forced vital capacity, idiopathic pulmonary fibrosis, nintedanib, pirfenidone, survival |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15100/00022168 |
|
ID登録タイプ |
JaLC |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine : General Internal Medicine, Omi Medical Center |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Nara Hospital |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Respiratory Medicine and Allergology, Kindai University Faculty of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 46,
号 2,
p. 57-64,
発行日 2021-12
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24327166 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Antifibrotic agents suppress the decline in forced vital capacity (FVC) and disease progression in patients with idiopathic pulmonary fibrosis (IPF). However, their effect on survival and the differences in this effect according to baseline FVC have not been explored. Thus, this study aimed to examine the effect of antifibrotics on survival and to investigate whether this effect differed according to baseline FVC. Consecutive patients with IPF from January 2008 to May 2019 were retrospectively examined. FVC at registration was used to categorize 172 patients into mild (n=77, FVC % predicted ≥ 80%), moderate (n=77, FVC % predicted 50-80%), and severe (n=18, FVC % predicted < 50%) groups. The mean FVC % predicted was 77.4 ± 22.2%. The median survival period of all patients was 3.82 years. The severe group showed significantly worse survival than the mild and moderate groups (p<0.0001 in both comparisons). Survival was significantly longer in patients with antifibrotic therapy, especially in the moderate group (p=0.04). The same tendency was observed in the mild group (p=0.18), but not in the severe group (p=0.93). In conclusion, antifibrotic therapy can extend the survival of IPF patients, especially in patients with an FVC % predicted of 50-80%. The effect in patients with FVC % predicted < 50 % should be further investigated. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20211200-0057.pdf (380.2 kB)
