{"created":"2023-06-20T16:49:52.583538+00:00","id":22191,"links":{},"metadata":{"_buckets":{"deposit":"28ecded1-54b0-4550-b9a4-2bf2ec96a2e5"},"_deposit":{"created_by":3,"id":"22191","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22191"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022191","sets":["14:2667:4710"]},"author_link":["43080"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18713/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18713/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：卵巣高異型度漿液性癌(HGSOC)は、約半数で相同組換え修復(HRR)の異常(HRD)が認められる。HGSOCのゲノムデータを解析し、HGSOCでのHRDを定量化したHRDスコアのカットオフ値を63が妥当であること、HRDを引き起こすHRR関連遺伝子の変異・エピジェネティック変異、それぞれの変異の有無で予後が異なること、化学療法前後でHRDスコアが変化すること、HRDスコアとBRCA1/2遺伝子変異、LOHの有無との関連性を明らかにした。研究成果の概要（英文）：We analyzed the genomic data of HGSOC and found that the cutoff value of HRD score, which quantifies HRD in HGSOC, is 63, and that mutations in HRR-related genes and epigenetic mutations, which cause HRD, have different prognoses. We also identified HRR-related gene mutations and epigenetic mutations that cause HRD, and found that the presence or absence of each mutation resulted in different prognoses. We also found that the HRD score changed before and after chemotherapy, and that the HRD score was associated with BRCA1/2 mutations and the presence of LOH.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2019～2020;   課題番号：19K18713;   研究分野：婦人科腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Takaya, Hisamitsu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高矢, 寿光"},{"creatorName":"タカヤ, ヒサミツ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"19K18713seika.pdf","filesize":[{"value":"87.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K18713seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22191/files/19K18713seika.pdf"},"version_id":"541e9b83-c518-4257-8c32-d4d8e3bf5154"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"卵巣癌","subitem_subject_scheme":"Other"},{"subitem_subject":"がんゲノム","subitem_subject_scheme":"Other"},{"subitem_subject":"相同組換修復","subitem_subject_scheme":"Other"},{"subitem_subject":"化学療法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"がんゲノムに基づく新たな卵巣がん薬剤感受性バイオマーカー探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"がんゲノムに基づく新たな卵巣がん薬剤感受性バイオマーカー探索"},{"subitem_title":"The exploration of new biomarker for chemo-sensitivity of ovarian cancer based on cancer genome","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22191","relation_version_is_last":true,"title":["がんゲノムに基づく新たな卵巣がん薬剤感受性バイオマーカー探索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:46:15.150818+00:00"}