{"created":"2023-06-20T16:49:52.540246+00:00","id":22190,"links":{},"metadata":{"_buckets":{"deposit":"e1a73f5d-cf68-490c-a8be-cfabe6f1df39"},"_deposit":{"created_by":3,"id":"22190","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22190"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022190","sets":["14:2667:4710"]},"author_link":["43338"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18480/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K18480/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、骨格筋が分泌するエクソソーム(Myo-exo)に着目し、筋・骨・血管連関における役割を検討した。Myo-exoは骨吸収を担う破骨細胞の形成を抑制するなど、骨に対する作用を示した。一方、血管の石灰化に対しては有効性を示さなかった。骨格筋は生体内で様々な力学的負荷を受け、骨格筋の性質にも影響をおよぼす。そこで力学的負荷を与えた筋細胞からMyo-exoを単離したところ、破骨細胞の形成抑制作用が増強された。また、Myo-exoに内包されるmiRNAを網羅的に解析し、見出された複数のmiRNAの作用を検討した結果、miR196がMyo-exoの破骨細胞抑制作用に重要である可能性が示された。研究成果の概要（英文）：We focused on exosomes secreted by skeletal muscle and investigated their roles in muscle-bone-vascular relationship. Exosomes secreted by muscle cells (Myo-exo) showed suppressive effects on formation of osteoclasts responsible for bone resorption, but were not effective against calcification of vascular smooth muscle cells. Mechanical stress is the critical extrinsic factor for skeletal muscle. Applying mechanical stress to muscle cells enhanced suppressive effect of Myo-exo on osteoclast formation. In addition, it was revealed that Myo-exo contains multiple miRNAs that suppress osteoclast formation by small RNA-seq-analysis. Among these miRNAs, miR196 may be important for the osteoclast inhibitory effect of Myo-exo.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2019～2020;   課題番号：19K18480;   研究分野：生理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TAKAFUJI, YOSHIMASA"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高藤, 義正"},{"creatorName":"タカフジ, ヨシマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43338","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90734864","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"19K18480seika.pdf","filesize":[{"value":"606.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K18480seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22190/files/19K18480seika.pdf"},"version_id":"3b5cdeff-f448-4841-9afc-36de9007aa63"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エクソソーム","subitem_subject_scheme":"Other"},{"subitem_subject":"miRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"筋","subitem_subject_scheme":"Other"},{"subitem_subject":"骨粗鬆症","subitem_subject_scheme":"Other"},{"subitem_subject":"筋・骨連関","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"骨粗鬆症における筋・骨・血管連関を担うエクソソームの役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"骨粗鬆症における筋・骨・血管連関を担うエクソソームの役割の解明"},{"subitem_title":"Roles of exosomes in muscle-bone-vascular linkage in osteoporosis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22190","relation_version_is_last":true,"title":["骨粗鬆症における筋・骨・血管連関を担うエクソソームの役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:46:13.112458+00:00"}