{"created":"2023-06-20T16:49:52.496791+00:00","id":22189,"links":{},"metadata":{"_buckets":{"deposit":"cc0cd171-5543-43bc-bbf1-666bbf70ce19"},"_deposit":{"created_by":3,"id":"22189","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22189"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022189","sets":["14:2667:4710"]},"author_link":["43339"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17506/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19K17506/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：腸内細菌の全身臓器への移行は膵炎患者においてしばしば観察されるが、慢性膵炎を制御する腸内細菌は同定されていない。実験慢性膵炎マウスの腸内細菌叢の解析の結果、腸管常在菌の1種であるAkkermansia muciniphila (A. muciniphila)の腸管からの消失が慢性膵炎の発症を促進する可能性が考えられた。A. muciniphilaは、自然免疫反応受容体TLR2またはTLR4を介して、膵臓へのマクロファージや樹状細胞の浸潤を防止し、膵腺房細胞からの炎症性サイトカインI型IFNとIL-33の産生を抑制することで慢性膵炎の発症を制御していると考えられた。研究成果の概要（英文）：Although bacterial translocation to systemic organs is sometimes observed in patients with pancreatitis, the gut microbiota accounting for the development of chronic pancreatitis has not been identified. In this study, we aimed to identify the gut microbiota that regulates the development of chronic pancreatitis and analyze its functions. According to the fecal microbiota analysis in experimental chronic pancreatitis, a disappearance of Akkermansia muciniphila (A. muciniphila) from the feces contributes to the development of chronic pancreatitis, whereas pancreatic enzyme replacement therapy may prevent the development of chronic pancreatitis by enhancing the colonization of A. muciniphila in the gastrointestinal tract. Increased colonization of A. muciniphila may prevent chronic pancreatitis by suppression of the infiltration of immune cells into the pancreas and by suppression of type I IFN and IL-33 productions by pancreatic acinar cells.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2019～2020;   課題番号：19K17506;   研究分野：消化器内科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Minaga, Kosuke"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学病院; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三長, 孝輔"},{"creatorName":"ミナガ, コウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43339","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30793814","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"19K17506seika.pdf","filesize":[{"value":"479.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"19K17506seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22189/files/19K17506seika.pdf"},"version_id":"057beb4e-63dc-4da2-8c3f-c61c7eaf1394"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性膵炎","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌","subitem_subject_scheme":"Other"},{"subitem_subject":"自然免疫反応","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性膵炎の発症を制御する腸内細菌の同定とその機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性膵炎の発症を制御する腸内細菌の同定とその機能解析"},{"subitem_title":"Identification of gut microbiota that regulates the development of chronic pancreatitis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22189","relation_version_is_last":true,"title":["慢性膵炎の発症を制御する腸内細菌の同定とその機能解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:46:11.459998+00:00"}