{"created":"2023-06-20T16:49:52.322817+00:00","id":22185,"links":{},"metadata":{"_buckets":{"deposit":"3e60c193-8769-46ab-a0f5-fd50444630d1"},"_deposit":{"created_by":3,"id":"22185","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22185"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022185","sets":["14:2667:4710"]},"author_link":["43342"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16751/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K16751/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：過活動膀胱が発生する機序に膀胱求心性神経のC-fiberの受容体TRPV1が関与していることが分かり、それを抑制するウイルスベクターを用いて、脊髄損傷マウスの膀胱壁に注射した。治療法として複製欠損単純ヘルペスウイルスベクターの膀胱局所注射を用いた理由はこのTRPV1拮抗薬を全身投与すると副作用が出る事が分かっており、局所療法が適していると考えた為である。研究の結果、脊髄損傷マウスモデルによる排尿筋の無抑制収縮（頻尿）を優位に減少させる結果が出た。以上の背景を踏まえ、新規ウイルスベクターを用いた新しい手法は、新規治療方法となりうる事が示唆された。研究成果の概要（英文）：SCI induces detrusor overactivity (DO), which is mediated by spinal reflexes triggered by hyperexcitable C-fiber afferent pathways. It has also been reported that TRPV1 receptors predominantly expressed in C-fibre afferent pathways greatly contribute to DO in SCI. However, the clinical application of TRPV1 antagonists for chronic pain has been hampered partly due to their adverse events such as hyperthermia. Hence, the development of local therapies that can target TRPV1 receptors expressed in the affected organs and their afferent pathways without inducing systemic adverse events would be useful for the treatment of DO in SCI. This study investigated the effect of HSV vectors-mediated gene delivery of non-functional, poreless TRPV1 or PP1α in storage and voiding dysfunction using SCI mice. Gene therapy with HSV vectors encoding poreless TRPV1 or PP1 α could be a novel treatment that can avoid systemic adverse events for hypersensitive bladder disorders such as SCI.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2018～2020;   課題番号：18K16751;   研究分野：下部尿路機能障害, 排尿薬理;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shimizu, Nobutaka"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"清水, 信貴"},{"creatorName":"シミズ, ノブタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K16751seika.pdf","filesize":[{"value":"185.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K16751seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22185/files/18K16751seika.pdf"},"version_id":"31ea7272-6b0d-4ad5-8f7a-825380b31485"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脊髄損傷マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"下部尿路機能障害","subitem_subject_scheme":"Other"},{"subitem_subject":"TRP channel","subitem_subject_scheme":"Other"},{"subitem_subject":"ウイルスベクター","subitem_subject_scheme":"Other"},{"subitem_subject":"β３アゴニスト","subitem_subject_scheme":"Other"},{"subitem_subject":"laser microd issection","subitem_subject_scheme":"Other"},{"subitem_subject":"膀胱求心路","subitem_subject_scheme":"Other"},{"subitem_subject":"脊髄後根神経節","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脊髄損傷マウスの下部尿路機能障害に対するウイルスベクターを用いた新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脊髄損傷マウスの下部尿路機能障害に対するウイルスベクターを用いた新規治療法の開発"},{"subitem_title":"Gene therapy with herpes simplex virus vectors improves lower urinary tract dysfunction in mice with spinal cord injury","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22185","relation_version_is_last":true,"title":["脊髄損傷マウスの下部尿路機能障害に対するウイルスベクターを用いた新規治療法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:46:03.938189+00:00"}