{"created":"2023-06-20T16:49:52.148520+00:00","id":22181,"links":{},"metadata":{"_buckets":{"deposit":"c0cb8da9-a06c-4a65-a329-bf53f782a382"},"_deposit":{"created_by":3,"id":"22181","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22181"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022181","sets":["14:2667:4710"]},"author_link":["33563","4034"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K11006/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K11006/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：末梢組織に蓄積するコレステロールは胆管経路以外にTICE(transintestinal cholesterol efflux)により血中から腸管へ直接排泄される。本研究では薬剤誘発性胆汁鬱滞や総胆管結紮により小腸LDLレセプターとAbcg5/g8が増加しTICEが増強した。さらに高脂血症治療薬であるエゼチミブやペマフィブラート投与により小腸Abcg5/g8の増加とTICEの亢進が認められた。ペマフィブラートでは吸収を担うNPC1L1とSR-B1が低下し、コレステロール吸収を抑制する可能性も示唆された。研究成果の概要（英文）：Any excessive cholesterol is transported back to the liver from the peripheral tissues and excreted in bile. In addition to the biliary route, transintestinal cholesterol efflux (TICE), a mechanism wherein cholesterol enters the small intestinal epithelial cells from the blood and is directly excreted into the intestinal lumen, was recently reported as a route of cholesterol excretion. In the present study, drug-induced cholestasis and bile duct ligation (BDL) induced intestinal expression of LDL receptor as well as Abcg5/g8 and enhanced fecal cholesterol excretion. Similarly, TICE pathway can be stimulated by lipid-lowering drugs ezetimibe and pemafibrate by increasing intestinal cholesterol efflux transporters Abcg5/g8. Furthermore, pemafibrate may suppress intestinal cholesterol absorption by reducing NPC1L1 and SR-B1. These data indicated that the small intestine may be a target organ for the prevention of atherosclerosis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K11006;   研究分野：病態代謝学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TANAKA, Yuji"},{"subitem_text_language":"en","subitem_text_value":"KAMISAKO, Toshinori"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学病院; 講師"},{"subitem_text_value":"近畿大学大学病院; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 裕滋"},{"creatorName":"タナカ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"4034","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00465650","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"上硲, 俊法"},{"creatorName":"カミサコ, トシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"33563","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20233934","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K11006seika.pdf","filesize":[{"value":"85.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K11006seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22181/files/18K11006seika.pdf"},"version_id":"a137113b-5f80-480c-83d0-f8d3d9fe5c04"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胆汁鬱滞","subitem_subject_scheme":"Other"},{"subitem_subject":"総胆管結紮","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質代謝異常","subitem_subject_scheme":"Other"},{"subitem_subject":"小腸","subitem_subject_scheme":"Other"},{"subitem_subject":"コレステロールトランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"TICE","subitem_subject_scheme":"Other"},{"subitem_subject":"エゼチミブペマフィブラート　","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胆汁鬱滞による脂質代謝異常に対する小腸の役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆汁鬱滞による脂質代謝異常に対する小腸の役割の解明"},{"subitem_title":"Role of the small intestine in dyslipidemia associated with cholestasis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22181","relation_version_is_last":true,"title":["胆汁鬱滞による脂質代謝異常に対する小腸の役割の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T19:45:55.911604+00:00"}