{"created":"2023-06-20T16:49:51.973989+00:00","id":22177,"links":{},"metadata":{"_buckets":{"deposit":"2d4884c8-253e-40bf-ad22-4c6617c76b2c"},"_deposit":{"created_by":3,"id":"22177","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22177"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022177","sets":["14:2667:4710"]},"author_link":["3264","30503","4038","4011","30504"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08493/ | https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K08493/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、疾患モデルマウスを用いて２型糖尿病関連形質の感受性遺伝子同定を行った。マウス14番染色体のテロメア側、11番染色体上の中央部に、ストレプトゾトシン感受性（膵β細胞脆弱性）遺伝子座をマップした。また、11番染色体に、高血糖感受性遺伝子座、インスリン分泌不全遺伝子座、脂肪蓄積遺伝子座を同定し報告した。ヒトを用いた研究では、２型糖尿病患者の表現型パネル作成を行っているが、その過程で特異な症例を発見し報告した。また、１型糖尿病・２型糖尿病・内分泌疾患における多数例での表現型解析、遺伝子解析を行った。研究成果の概要（英文）：In this study, we identified susceptibility genes for type 2 diabetes-related traits using a mouse model of the disease. We mapped streptozotocin susceptibility (pancreatic β-cell vulnerability) loci to the telomeric side of mouse chromosome 14 (Int J Endocrinol 2018) and to the central region on chromosome 11 (Mamm Genome 2018). We also identified and reported hyperglycemia-sensitive, insulin deficient, and fat accumulation loci on chromosome 11 (BMC Genet 2020). In human studies, we are creating a phenotypic panel of type 2 diabetic patients, and in the process, we discovered and reported unique cases (J Endocr Soc 2018, J Endocr Soc 2021). We also performed phenotyping and genetic analysis in a large number of cases in type 1 diabetes, type 2 diabetes, and endocrine disorders (J Diabetes Investig 2018, J Diabetes Investig 2020, Sci Rep 2021).","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K08493;   研究分野：内分泌・糖尿病;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"BABAYA, naru"},{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"KAWABATA, Yumiko"},{"subitem_text_language":"en","subitem_text_value":"NOSO, Shinsuke"},{"subitem_text_language":"en","subitem_text_value":"HIROMINE, Yoshihisa"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"馬場谷, 成"},{"creatorName":"ババヤ, ナル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池上, 博司"},{"creatorName":"イケガミ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川畑, 由美子"},{"creatorName":"カワバタ, ユミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"能宗, 伸輔"},{"creatorName":"ノウソウ, シンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"廣峰, 義久"},{"creatorName":"ヒロミネ, ヨシヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K08493seika.pdf","filesize":[{"value":"168.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K08493seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22177/files/18K08493seika.pdf"},"version_id":"fe8fbf02-5dec-4f46-9639-071162c6d36c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"疾患感受性遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"２型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"NSYマウス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"２型糖尿病における遺伝子・環境相互連関情報ネットワークの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"２型糖尿病における遺伝子・環境相互連関情報ネットワークの解明"},{"subitem_title":"The elucidation of gene-environment interaction network in type 2 diabetes","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22177","relation_version_is_last":true,"title":["２型糖尿病における遺伝子・環境相互連関情報ネットワークの解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T19:43:46.375177+00:00"}