{"created":"2023-06-20T16:49:51.887156+00:00","id":22175,"links":{},"metadata":{"_buckets":{"deposit":"4b81445f-87b9-4277-918d-4b0c15397b37"},"_deposit":{"created_by":3,"id":"22175","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22175"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022175","sets":["14:2667:4710"]},"author_link":["3543","3742"],"control_number":"22175","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07984/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：HBx C1485T変異の存在下では活性酸素の産生亢進やJNK経路の活性化が誘導される結果、肝癌の発症が促進されていることを見出した。またHBxC1485T変異の存在下に誘導される腫瘍微小免疫環境を解明では、TAMsやMDSCsの細胞数が抑制されており、抗腫瘍効果の要因の一つであることが証明された。研究成果の概要（英文）：It was found that the onset of liver cancer was promoted as a result of increased production of active oxygen and activation of the JNK pathway in the presence of the HBx C1485T mutation. In addition, elucidation of the tumor microimmune environment induced in the presence of the HBxC1485T mutation proved that the cell numbers of TAMs and MDSCs were suppressed, which is one of the factors of the antitumor effect.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K07984;   研究分野：Tumor microimmune environment;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HAGIWARA, Satoru"},{"subitem_text_language":"en","subitem_text_value":"KUDO, Masatoshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"萩原, 智"},{"creatorName":"ハギワラ, サトル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"工藤, 正俊"},{"creatorName":"クドウ, マサトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K07984seika.pdf","filesize":[{"value":"277.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K07984seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22175/files/18K07984seika.pdf"},"version_id":"01efab40-cc34-4aeb-a1e8-6829112a6a6e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝癌惹起性HBx変異　腫瘍微小免疫環境","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝癌惹起性HBx変異の存在下で形成される腫瘍微小免疫環境の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝癌惹起性HBx変異の存在下で形成される腫瘍微小免疫環境の解析","subitem_title_language":"ja"},{"subitem_title":"Analysis of tumor microimmune environment formed in the presence of liver cancer-induced HBx mutations","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22175","relation_version_is_last":true,"title":["肝癌惹起性HBx変異の存在下で形成される腫瘍微小免疫環境の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-14T06:27:00.722000+00:00"}