{"created":"2023-06-20T16:49:51.843309+00:00","id":22174,"links":{},"metadata":{"_buckets":{"deposit":"f8905c63-7ad9-43ba-b2fd-cd0976893848"},"_deposit":{"created_by":3,"id":"22174","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22174"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022174","sets":["14:2667:4710"]},"author_link":["3742","33539"],"control_number":"22174","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"16","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07922/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：肝細胞癌(肝癌）において、癌関連シグナルの変化は腫瘍微小免疫環境に影響する可能性がある。本解析により、PD-L1陽性肝癌は腫瘍浸潤リンパ球(TIL)が多く、PI3K-Akt活性型変異が多いことが確認された。一方、β-カテニン経路の活性型変異を持つ肝癌はPD-L1陰性かつTILに乏しかった。ICI治療を受けた肝癌例では、β-カテニン経路活性化の有無, TIL, PD-L1の状態で治療における予後を層別化できた。PD-L1陽性肝癌はPI3K-Akt活性に介在するチロシンキナーゼ阻害剤の併用が有効である可能性がある。一方、PD-L1陰性肝癌はβ-カテニン阻害剤の影響を検討する余地がある。研究成果の概要（英文）：To know how the effectively the response to immune checkpoint inhibitors (ICIs) can be enhanced, we explored the immunological and molecular characteristics of HCCs.Programmed cell death ligand 1 (PD-L1)-positive HCCs frequently showed inflamed phenotype; a subset of HCCs carried mutation in PI3K-Akt pathway. In HCCs with infiltration of TILs, CD8+ cells expressed multiple co-inhibitory receptors, suggesting T-cell exhaustion. On the other hands, PD-L1-negative HCCs showed activating mutations in β-catenin, such tumor exhibited non-inflamed phenotype. Through the analysis of the HCC patients treated with anti-PD-1 therapy, the combined of Wnt/β-catenin activation, PD-L1 expression, and degree of CD8+ TILs in HCC are revealed to be the predicting factor for the response to ICI. Tyrosine kinase inhibitor involving PI3K/Akt pathway, in combination with ICI, might effective in HCC with mutation in PI3K-Akt. Role of β-catenin inhibitor on immune cold HCC should also be explored.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K07922;   研究分野：消化器内科;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KUDO, Masatoshi"},{"subitem_text_language":"en","subitem_text_value":"NISHIDA, Naoshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"工藤, 正俊"},{"creatorName":"クドウ, マサトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西田, 直生志"},{"creatorName":"ニシダ, ナオシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K07922seika.pdf","filesize":[{"value":"640.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K07922seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22174/files/18K07922seika.pdf"},"version_id":"92c12cd1-93f7-4154-a5ff-3a2e57814680"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝細胞癌","subitem_subject_scheme":"Other"},{"subitem_subject":"微小免疫環境","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫チェックポイント阻害剤","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ阻害剤","subitem_subject_scheme":"Other"},{"subitem_subject":"PI3K-Akt経路","subitem_subject_scheme":"Other"},{"subitem_subject":"β-catenin経路","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌におけるチロシンキナーゼ阻害剤の免疫微小環境への影響に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌におけるチロシンキナーゼ阻害剤の免疫微小環境への影響に関する研究","subitem_title_language":"ja"},{"subitem_title":"Effect of tyrosine kinase inhibitor for immunological microenviroment of hepatocellular carcinoma","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22174","relation_version_is_last":true,"title":["肝細胞癌におけるチロシンキナーゼ阻害剤の免疫微小環境への影響に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-14T08:37:53.316435+00:00"}