{"created":"2023-06-20T16:49:51.665899+00:00","id":22170,"links":{},"metadata":{"_buckets":{"deposit":"c2268533-ea86-40e9-b469-09afae40aa62"},"_deposit":{"created_by":3,"id":"22170","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22170"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022170","sets":["14:2667:4710"]},"author_link":["30532"],"control_number":"22170","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"8","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06941/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ヒストン脱メチル化酵素が乳がんに与える影響を調べるため、ヒストン脱メチル化酵素であるUTXおよびKDM4Bの乳腺組織特異的ノックアウトマウスを用いて、乳がん発症マウス(MMTV-PyMTマウス)に及ぼす影響を検討した。その結果、Utx欠損とMMTV-PyMTの複合変異を持つ乳がん発症マウスでは腫瘍増殖や肺転移、浸潤能が促進していた。一方、Kdm4b欠損とMMTV-PyMTの複合変異を持つ乳がん発症マウスでは腫瘍増殖が抑制される結果を得た。KDM4Bの欠損は乳がん細胞の発生もしくは増殖を抑制する可能性が示唆された。研究成果の概要（英文）：UTX is a histone demethylase that targets di- and tri-methylated histone H3 lysine 27 (H3K27me2/3) and KDM4B is a histone H3K9me2/3 demethylase. To study the effect of histone demethylase UTX and KDM4B loss on breast cancer in vivo, we have generated the mouse mammary tumor virus-polyoma middle T antigen (MMTV-PyMT) model of breast cancer lacking Utx or Kdm4b. We found that Utx deficiency accelerates tumor development and lung metastasis. Furthermore, breast tumor organoids isolated from Utx-deficient MMTV-PyMT mice showed highly invasive phenotype in 3D culture. These results suggested that deletion or decreased expression of UTX may promote human breast cancer progression, implicating clinical relevance of UTX in breast cancer treatment and/or diagnosis. On the other hand, loss of KDM4B suppressed the growth of mouse mammary tumor and prolonged the survival of MMTV-PyMT breast cancer mice. The inhibitor of KDM4B may have the therapeutic effect on breast cancer.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K06941;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KOMURO, Akiyoshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"古室, 暁義"},{"creatorName":"コムロ, アキヨシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18K06941seika.pdf","filesize":[{"value":"101.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K06941seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22170/files/18K06941seika.pdf"},"version_id":"858ec760-80da-4332-9bf8-6d19a3f2f885"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エピジェネティクス","subitem_subject_scheme":"Other"},{"subitem_subject":"乳がん","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"乳がん悪性化におけるHistone demethylaseの役割と治療法の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"乳がん悪性化におけるHistone demethylaseの役割と治療法の探索","subitem_title_language":"ja"},{"subitem_title":"Role of histone demethylase in breast cancer progression and finding new therapeutic approaches for breast cancer","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22170","relation_version_is_last":true,"title":["乳がん悪性化におけるHistone demethylaseの役割と治療法の探索"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-15T02:01:37.865060+00:00"}