{"created":"2023-06-20T16:49:51.534844+00:00","id":22167,"links":{},"metadata":{"_buckets":{"deposit":"65a4f724-746e-469e-b4c1-18e0c39e1d7d"},"_deposit":{"created_by":3,"id":"22167","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22167"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022167","sets":["14:2667:4710"]},"author_link":["3178","33593","3254"],"control_number":"22167","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18H02745/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：免疫性神経疾患の自己抗体の標的抗原として、リン脂質やコレステロールと糖脂質の組み合わせを網羅的に検討した。慢性炎症性脱髄性多発ニューロパチーで、Gal-CやSulfatideなどミエリン局在性の糖脂質と脂質の混合抗原に対する特異的なIgM抗体反応が多く検出され、病態との関連が示唆された。多巣性運動ニューロパチーでは約半数でIgM抗GM1抗体が陽性となるが、フォスファチジン酸をGM1に添加することで陽性率が高まることがわかった。IgG抗GD1a抗体は予後不良なギラン・バレー症候群と関連すること、ビッカースタッフ脳幹脳炎でGQ1b関連抗体陽性例は均一な臨床特徴を示すことが明らかとなった。研究成果の概要（英文）：Autoantibodies in neuroimmunological diseases against complex antigens formed by glycolipids and phospholipids or cholesterol were investigated. IgM antibodies to complex antigens including such myelin antigens as Gal-C and sulfatide were frequently detected in chronic inflammatory demyelinating polyneuropathy. Those antibodies may be involved in the pathogenetic mechanism of demyelination. In multifocal motor neuropathy, the positive rate of IgM anti-GM1 antibodies was increased when phosphatidic acid was added to the GM1 antigen. IgG anti-GD1a antibodies were found to be associated with Guillain-Barre syndrome with poor prognosis. Patients with Bickerstaff brainstem encephalitis having GQ1b-related antibodies showed relatively uniform clinical features.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(B);  研究期間：2018～2020;   課題番号：18H02745;   研究分野：神経内科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KUSUNOKI, Susumu"},{"subitem_text_language":"en","subitem_text_value":"KUWAHARA, Motoi"},{"subitem_text_language":"en","subitem_text_value":"MIYAMOTO, Katsuichi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 客員教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"楠, 進"},{"creatorName":"クスノキ, ススム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"桑原, 基"},{"creatorName":"クワハラ, モトイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"宮本, 勝一"},{"creatorName":"ミヤモト, カツイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"18H02745seika.pdf","filesize":[{"value":"94.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18H02745seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22167/files/18H02745seika.pdf"},"version_id":"81444b1a-55a8-465a-9869-4889a7b1003c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"免疫性神経疾患","subitem_subject_scheme":"Other"},{"subitem_subject":"自己抗体","subitem_subject_scheme":"Other"},{"subitem_subject":"糖脂質","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質複合体","subitem_subject_scheme":"Other"},{"subitem_subject":"ガングリオシド","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"免疫性神経疾患における脂質２分子の複合体に対する自己抗体の解析と病因的意義の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"免疫性神経疾患における脂質２分子の複合体に対する自己抗体の解析と病因的意義の解明","subitem_title_language":"ja"},{"subitem_title":"Investigation of the autoantibodies against complex antigens formed by two lipid molecules in neuroimmunological diseases","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22167","relation_version_is_last":true,"title":["免疫性神経疾患における脂質２分子の複合体に対する自己抗体の解析と病因的意義の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-14T06:29:59.500816+00:00"}