{"created":"2023-06-20T16:49:51.448902+00:00","id":22165,"links":{},"metadata":{"_buckets":{"deposit":"02186d28-fcda-471d-80da-970e54c4e297"},"_deposit":{"created_by":3,"id":"22165","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22165"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022165","sets":["14:2667:4710"]},"author_link":["43358","3356","3960"],"control_number":"22165","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K01487/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は、加齢性の筋減退である「サルコペニア」における組織恒常性の破綻を解明するため、筋衛星細胞に注目し、抗酸化マスター遺伝子であるNrf2、活性酸素、老化で低下するオーファジー（自食作用）と筋恒常性の関連の検討である。Nrf2の発現低下は、炎症や細胞老化に関わるmiRNA-155の発現を上昇させることを見出した。また、miRNA-155とオートファジーの関りについては、筋芽細胞細胞株C2C12において、miRNA-155がミトコンドリア選択的オートファジーの阻害に関わることを発見した。以上より加齢性の筋減退はmiRNA-155の多面的な作用により惹起されるという研究成果を得た。研究成果の概要（英文）：In this study, we focused on muscle satellite cells in order to elucidate the breakdown of tissue homeostasis in \"sarcopenia,\" which is age-related muscle decline. We have been studying the relationship between the antioxidant master gene Nrf2, reactive oxygen species, aging-decreased autophagy, and muscle　homeostasis. It was found that decreased expression of Nrf2 increased the expression of miRNA-155, which is involved in inflammation and cell aging. Regarding the relationship between miRNA-155 and autophagy, we found that miRNA-155 is involved in the inhibition of mitochondrial selective autophagy in the myoblast cell line C2C12. From the above, we obtained research results that age-related muscle decline is caused by the multifaceted action of miRNA-155.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：17K01487;   研究分野：リハビリテーション;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Itokazu, Maki"},{"subitem_text_language":"en","subitem_text_value":"Teramura, Takeshi"},{"subitem_text_language":"en","subitem_text_value":"Fukuda, kanji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学病院; 助教"},{"subitem_text_value":"近畿大学大学病院; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"糸数, 万紀"},{"creatorName":"イトカズ, マキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43358","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90780015","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=90780015"}]},{"creatorNames":[{"creatorName":"寺村, 岳士"},{"creatorName":"テラムラ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3356","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40460901","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=40460901"}]},{"creatorNames":[{"creatorName":"福田, 寛二"},{"creatorName":"フクダ, カンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3960","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50201744","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=50201744"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"17K01487seika.pdf","filesize":[{"value":"277.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K01487seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22165/files/17K01487seika.pdf"},"version_id":"a7f87d81-1321-4db5-a959-b023cd2bec99"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"サルコペニア","subitem_subject_scheme":"Other"},{"subitem_subject":"筋衛星細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"Nrf2","subitem_subject_scheme":"Other"},{"subitem_subject":"miRNA-155","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"加齢性筋委縮症における筋衛星細胞の恒常性変化とNrf2/オートファジー系の関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"加齢性筋委縮症における筋衛星細胞の恒常性変化とNrf2/オートファジー系の関与","subitem_title_language":"ja"},{"subitem_title":"Homeostatic changes in muscle satellite cells and involvement of Nrf2 / autophagy system in age-related myopathy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22165","relation_version_is_last":true,"title":["加齢性筋委縮症における筋衛星細胞の恒常性変化とNrf2/オートファジー系の関与"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-14T09:10:26.893856+00:00"}