{"created":"2023-06-20T16:49:51.362962+00:00","id":22163,"links":{},"metadata":{"_buckets":{"deposit":"937d21f5-f055-48cb-9385-4a295a09bd13"},"_deposit":{"created_by":3,"id":"22163","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22163"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022163","sets":["14:2667:4710"]},"author_link":["43364","43365","3994","3706","43059","43366","43367","43412"],"control_number":"22163","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10368/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：この研究の目的は11C-methionine (MET) PET/CTと神経膠腫で手術を受けた患者を対象に、アミノ酸代謝や細胞増殖シグナル伝達因子とMETの相関性を見つけ、MET集積と細胞増殖シグナル伝達因子を用いて予後予測因子を検討し、脳腫瘍の腫瘍増殖とアミノ酸代謝との関係について病理学的解明を試みる事である。この検討においてMET集積機序にアミノ酸トランスポータのLAT-1が関係し、MET集積は神経膠腫の悪性度だけではなく、EGFR の発現予測への可能性が示された。同時にLAT-1の発現には腫瘍内低酸素の関与が考えられた。研究成果の概要（英文）：The aim of this study is to reveal the correlation and prognostic factors among 11C-methionine (MET) uptake and signal transduction factors and to investigate the pathological relationship between amino acid metabolism and tumor cell proliferation in glioma patients undergoing both PET/CT and operation. Our data showed that MET uptake in glioma had positive correlation with L-type amino acid transporter-1 (LAT-1) and that MET uptake in glioma have potential role in predicting both the degree of malignancy and epidermal growth factor receptor (EGFR). Our data also suggest that LAT-1 expression may be related with tumor hypoxia.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2016～2020;   課題番号：16K10368;   研究分野：腫瘍核医学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAIDA, HAYATO"},{"subitem_text_language":"en","subitem_text_value":"Ishii, Kazunari"},{"subitem_text_language":"en","subitem_text_value":"Kato, Amami"},{"subitem_text_language":"en","subitem_text_value":"Ito, Akihiko"},{"subitem_text_language":"en","subitem_text_value":"Murakami, Takumichi"},{"subitem_text_language":"en","subitem_text_value":"Hattori, Satoshi"},{"subitem_text_language":"en","subitem_text_value":"Kawahara, Akihiko"},{"subitem_text_language":"en","subitem_text_value":"Okuda, Takeshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"神戸大学医学研究科; 教授"},{"subitem_text_value":"大阪大学医学系研究科; 教授"},{"subitem_text_value":"久留米大学大学病院; 医療技術員"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":""},{"subitem_text_value":""},{"subitem_text_value":""},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"甲斐田, 勇人"},{"creatorName":"カイダ, ハヤト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"石井, 一成"},{"creatorName":"イシイ, カズナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"加藤, 天美"},{"creatorName":"カトウ, アマミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"伊藤, 彰彦"},{"creatorName":"イトウ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村上, 卓道"},{"creatorName":"ムラカミ, タクミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"服部, 聡"},{"creatorName":"ハットリ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"河原, 明彦"},{"creatorName":"カワハラ, アキヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"奥田, 武司"},{"creatorName":"オクダ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-25"}],"displaytype":"detail","filename":"16K10368seika.pdf","filesize":[{"value":"81.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"16K10368seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22163/files/16K10368seika.pdf"},"version_id":"302096fe-6989-450c-a384-0af53bd1d3a9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脳腫瘍","subitem_subject_scheme":"Other"},{"subitem_subject":"アミノ酸イメージング","subitem_subject_scheme":"Other"},{"subitem_subject":"癌シグナル伝達因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アミノ酸イメージングと癌シグナル伝達因子による脳腫瘍患者の予後予測マーカーの解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アミノ酸イメージングと癌シグナル伝達因子による脳腫瘍患者の予後予測マーカーの解明","subitem_title_language":"ja"},{"subitem_title":"To elucidate the prognostic marker using amino acid PET imaging and signal transduction factors in brain tumor patients","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-25"},"publish_date":"2021-11-25","publish_status":"0","recid":"22163","relation_version_is_last":true,"title":["アミノ酸イメージングと癌シグナル伝達因子による脳腫瘍患者の予後予測マーカーの解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-14T08:53:30.879560+00:00"}