{"created":"2023-06-20T16:49:50.683910+00:00","id":22148,"links":{},"metadata":{"_buckets":{"deposit":"13e5bf27-c536-47e5-88c1-36ef4db9f068"},"_deposit":{"created_by":3,"id":"22148","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22148"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022148","sets":["14:2667:4710"]},"author_link":["3848"],"control_number":"22148","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K05541/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：我々は魚類由来エラスチンぺプチドが白血球と内皮細胞の接着抑制を介して高血圧性腎血管障害を抑制することを明らかにした。Dipeptidyl Peptidase-IV（DPP-IV)はインクレチンの分解の他、炎症部位に好発現することが知られている。そこで、エラスチンペプチドがDPP-IV阻害活性を有無を確認したところ低分子のエラスチンペプチドが強いDPP-IV阻害活性を有することを確認した。今後は、DPP-4阻害剤投与とエラスチンペプチド摂取による血管傷害抑制効果の差異を明らかにし、高血圧性血管障害と糖代謝異常発症抑制効果を有する機能性食品成分としてのエラスチンペプチドの有用性を明らかにする。研究成果の概要（英文）：In this study, we revealed that fish-derived elastin peptides prevent the occurene of hypertensive renal vascular dysfunctions, which mediated by suppressing adhesion between leukocytes and endothelial cells. Dipeptidyl peptidase IV (DPP-IV) is known to be expressed at the site of inflammatory lesions, as well as have the degrading action of incretin. We confirmed that the low molecule elastin peptides have DPP-IV inhibition activity. In the future, we will clarify the usefulness of elastin peptide as a functional food with protective effect against tne onset of hypertensive and diabetic vascular injuries.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K05541;   研究分野：実験病理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Takemori, Kumiko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹森, 久美子"},{"creatorName":"タケモリ, クミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-10"}],"displaytype":"detail","filename":"18K05541seika .pdf","filesize":[{"value":"98.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K05541seika .pdf","url":"https://kindai.repo.nii.ac.jp/record/22148/files/18K05541seika .pdf"},"version_id":"9b5f5c82-5864-4935-bbb5-0e795a5d3f92"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"エラスチン","subitem_subject_scheme":"Other"},{"subitem_subject":"高血圧","subitem_subject_scheme":"Other"},{"subitem_subject":"SHRSP","subitem_subject_scheme":"Other"},{"subitem_subject":"腎血管障害","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"魚類由来エラスチンペプチド摂取による腎血管保護作用の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"魚類由来エラスチンペプチド摂取による腎血管保護作用の解明","subitem_title_language":"ja"},{"subitem_title":"An evaluation of the protective effects of elastin peptide obtained from fish bulbus arteriosus in renal arteries","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-10"},"publish_date":"2021-11-10","publish_status":"0","recid":"22148","relation_version_is_last":true,"title":["魚類由来エラスチンペプチド摂取による腎血管保護作用の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-13T06:59:47.546126+00:00"}