{"created":"2023-06-20T16:49:50.221121+00:00","id":22140,"links":{},"metadata":{"_buckets":{"deposit":"d7d25639-1d4d-4083-ae9d-8e2c57ec2f69"},"_deposit":{"created_by":3,"id":"22140","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22140"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022140","sets":["14:2667:4710"]},"author_link":["43310"],"control_number":"22140","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K14965/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：脂質メディエーターの一種であるプロスタグランジンE2(PGE2)は様々な原因による肝障害を抑制する肝保護因子として作用する。本研究では特異体質性に惹起される場合が多い薬物誘発性肝障害の発症の個体差の原因に、脂質メディエーター輸送体の機能変動が影響するかを明らかにすることを目的とした。結果として、PGE2の輸送体である有機アニオン輸送体 (OATP2A1)が、肝臓では肝血管内皮とクッパー細胞に主に発現し、肝障害の種類によって発現変動が異なることが明らかになった。また、輸送体に加えて肝障害時の肝PGE2量調節にはPGE2不活化酵素 (15-PGDH)が重要な役割を果たすことが示された。研究成果の概要（英文）：Prostaglandin E2, one of the lipid mediators, serves as hepatoprotective factor against liver injury triggered by various causes. The purpose of present study is clarifying the impact of alteration of lipid mediator transporter activity on individual development of drug-induced liver injury that occurred in an idiosyncratic manner. Present results suggest that organic-anion transporting polypeptide (OATP) 2A1 that serves as PGE2 transporter is expressed in endothelial cells and Kupffer cells and its expression level is complexly regulated dependent on the types of liver injury. In addition to OATP2A1, moreover, it is revealed that hepatic 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a PGE2 inactivation enzyme, has a great impact on the regulation of hepatic PGE2 amount under liver injury conditions.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2018～2020;   課題番号：18K14965;   研究分野：薬物動態学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shimada, Hiroaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"島田, 紘明"},{"creatorName":"シマダ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43310","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40783444","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=40783444"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-08"}],"displaytype":"detail","filename":"18K14965seika.pdf","filesize":[{"value":"84.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K14965seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22140/files/18K14965seika.pdf"},"version_id":"df7a11c1-57cb-44bd-86d6-619561f03272"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝障害","subitem_subject_scheme":"Other"},{"subitem_subject":"脂質メディエーター","subitem_subject_scheme":"Other"},{"subitem_subject":"PGE2","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"代謝酵素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂質メディエーター輸送体の機能変動が薬物誘発性肝障害発症の個体差に与える影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂質メディエーター輸送体の機能変動が薬物誘発性肝障害発症の個体差に与える影響","subitem_title_language":"ja"},{"subitem_title":"Impact of alteration of lipid mediator transporter activity on interindividual variety of development of drug-induced liver injury","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-08"},"publish_date":"2021-11-08","publish_status":"0","recid":"22140","relation_version_is_last":true,"title":["脂質メディエーター輸送体の機能変動が薬物誘発性肝障害発症の個体差に与える影響"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-13T06:37:24.549383+00:00"}