{"created":"2023-06-20T16:49:50.056628+00:00","id":22137,"links":{},"metadata":{"_buckets":{"deposit":"f8860e9c-5b24-46a9-9118-17c51e1e58ae"},"_deposit":{"created_by":3,"id":"22137","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22137"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022137","sets":["14:2667:4710"]},"author_link":["3137","43371","3143"],"control_number":"22137","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K07249/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：生理活性脂質のひとつであるリゾフォスファチジン酸（LPA、lysophosphatidicacid）は、Gタンパク質共役型LPA受容体（LPA1-LPA6）に特異的に結合することで様々な細胞応答を誘発する。本研究では、抗がん剤処理によるがん細胞の生物学的特性の変化にどのようにLPA受容体シグナルが関与するかを明らかにする目的で、短期・長期間抗がん剤処理を種々のがん細胞に行い細胞機能への影響を解析した。その結果、抗がん剤処理によるがん細胞の運動・浸潤および抗がん剤に対する細胞生存率の制御にLPA受容体を介する細胞内シグナルが重要な役割を担うことが判明した。研究成果の概要（英文）：Lysophosphatidic acid (LPA) is a simple lipid and mediates various biological responses through the binding of G protein-coupled LPA receptors. Six subtypes of LPA receptors (LPA1) to LPA6) have been identified so far. It is considered that LPA receptor signaling is involved in the pathogenesis of human diseases, including cancer. In this study, we investigated the roles of LPA receptor signaling in the cellular functions induced by anticancer drug treatment in cancer cells. Our results have shown that the individual LPA receptors regulate cell motility, invasion and metastasis in cancer cells treated with anticancer drugs. Moreover, the activation of LPA receptor-mediated signaling promotes the modulation of anticancer drug resistance in cancer cells. Therefore, it is suggested that LPA receptor signaling is a potent pharmacological target for the establishment of effective chemotherapeutic agents.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K07249;   研究分野：分子腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Tsujiuchi, Toshifumi"},{"subitem_text_language":"en","subitem_text_value":"Honoki, Kanya"},{"subitem_text_language":"en","subitem_text_value":"Fukushima, Nobuyuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 教授"},{"subitem_text_value":"奈良県立医科大学医学部; 教授"},{"subitem_text_value":"近畿大学理工学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":""},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"辻内, 俊文"},{"creatorName":"ツジウチ, トシフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"朴木, 寛弥"},{"creatorName":"フクシマ, ノブユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{"nameIdentifierURI":""}]},{"creatorNames":[{"creatorName":"福嶋, 伸之"}],"nameIdentifiers":[{},{"nameIdentifierURI":""}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-08"}],"displaytype":"detail","filename":"18K07249seika.pdf","filesize":[{"value":"105.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K07249seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22137/files/18K07249seika.pdf"},"version_id":"2d3e92b8-780e-4714-8fd2-852c9b9085cd"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リゾフォスファチジン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"LPA受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"がん細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"抗がん剤","subitem_subject_scheme":"Other"},{"subitem_subject":"抗がん剤抵抗性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"抗がん剤によるがん細胞の生物学的特性の変化とＬＰＡ受容体シグナルの役割","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"抗がん剤によるがん細胞の生物学的特性の変化とＬＰＡ受容体シグナルの役割","subitem_title_language":"ja"},{"subitem_title":"Roles of LPA receptors in the acquisition of malignant properties in cancer cells treated with anticancer drugs","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-08"},"publish_date":"2021-11-08","publish_status":"0","recid":"22137","relation_version_is_last":true,"title":["抗がん剤によるがん細胞の生物学的特性の変化とＬＰＡ受容体シグナルの役割"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-13T06:19:50.700347+00:00"}