{"created":"2023-06-20T16:49:49.922771+00:00","id":22135,"links":{},"metadata":{"_buckets":{"deposit":"f85106d6-c054-4f57-b0bf-0046640d7d25"},"_deposit":{"created_by":3,"id":"22135","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22135"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022135","sets":["14:2667:4710"]},"author_link":["43372"],"control_number":"22135","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K06805/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ジゴキシンとがんとの関連について、有害事象自発報告データベースと大規模レセプトデータベースを用い、Disproportionality analysisおよびでSymmetry analysisでシグナル検出を行った結果、胃がん、大腸がん、前立腺がん、血液のがんでドラッグ・リポジショニング・シグナル（DRS）を検出した。得られたDRSについて、BaseSpace Correlation Engineなどの遺伝子発現データベースの解析により、DRSをさらに補強する結果が得られた。リアルワールドデータと遺伝子発現データベースを用いる手法は、DRSの検出に有用であると考えられた。研究成果の概要（英文）：Disproportionality analysis and symmetry analysis using a spontaneous adverse event reporting database and a large claims database were performed to investigate the relationship between digoxin and cancer. As a result, drug repositioning signal (DRS) was detected for gastric, colon, prostate, and blood cancers. Additionally, analysis of a gene expression database such as BaseSpace Correlation Engine supported the DRS obtained from disproportionality analysis and symmetry analysis. Therefore, the methodology using real-world data and gene expression data were useful for the detection of DRS.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2018～2020;   課題番号：18K06805;   研究分野：薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Takada, Mitsutaka"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"高田, 充隆"},{"creatorName":"タカダ, ミツタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-08"}],"displaytype":"detail","filename":"18K06805seika.pdf","filesize":[{"value":"84.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K06805seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22135/files/18K06805seika.pdf"},"version_id":"4a102a90-4c8c-409f-872d-6502d101b090"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リアルワールドデータ","subitem_subject_scheme":"Other"},{"subitem_subject":"ビッグデータ","subitem_subject_scheme":"Other"},{"subitem_subject":"有害事象自発報告","subitem_subject_scheme":"Other"},{"subitem_subject":"レセプト","subitem_subject_scheme":"Other"},{"subitem_subject":"ドラッグ・リポジショニング","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"リアルワールドデータによるドラッグ・リポジショニング・シグナル検出方法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"リアルワールドデータによるドラッグ・リポジショニング・シグナル検出方法の開発","subitem_title_language":"ja"},{"subitem_title":"Development of drug repositioning signal detection method using real-world data","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-08"},"publish_date":"2021-11-08","publish_status":"0","recid":"22135","relation_version_is_last":true,"title":["リアルワールドデータによるドラッグ・リポジショニング・シグナル検出方法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-13T06:32:21.525580+00:00"}