{"created":"2023-06-20T16:49:48.601059+00:00","id":22110,"links":{},"metadata":{"_buckets":{"deposit":"69c92c57-ad12-4fa3-9bfc-a6d4f77edc4a"},"_deposit":{"created_by":3,"id":"22110","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"22110"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00022110","sets":["14:2667:4710"]},"author_link":["43282","43281"],"control_number":"22110","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2020)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K08500/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：細胞の増殖や分化、移動などが盛んにおこなわれる胎生期の脳神経系は、化学物質やストレス曝露、感染症の罹患などの環境要因に対して高感受性である。この時期の神経細胞の分化や成熟、投射など細胞動態への影響は、先天奇形や脳機能異常を引き起こす可能性がある。この原因の一つとして、ミクログリアの異常な活性化や脳内炎症に注目した。これらは様々な化学物質やストレスの胎児期曝露、さらには感染症への罹患によって幅広く起きている現象であることを示した。つまり、大脳皮質や海馬歯状回の形態形成や機能成熟が、様々な環境因子に起因する脳内炎症によって妨げられ、それが先天奇形や発達障害の原因となっている可能性が示された。研究成果の概要（英文）：The central nerve system during the prenatal period, in which cells proliferate, neurognesis, and neuronal migration, is highly sensitive to environmental factors such as chemical substances, stress exposure, and infectious diseases. Effects on cell dynamics such as neurogensis, maturation, and neuronal projection during this period can cause congenital malformations and brain dysfunctio0n.We focused on abnormal activation of microglia and inflammation in the developing brain. These have been shown to be widespread phenomena due to prenatal exposure to various chemicals and stresses, as well as infectious diseases. In other words, it was shown that morphogenesis and functional maturation of the cerebral cortex and hippocampal dentate gyrus may be hindered by inflammation in the brain caused by various environmental factors, which may cause congenital malformations and developmental disorders.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2020;   課題番号：17K08500;   研究分野：神経発生毒性学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Komada, Munekazu"},{"subitem_text_language":"en","subitem_text_value":"Nagao, Tetsuji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学理工学部; 講師"},{"subitem_text_value":"近畿大学理工学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"駒田, 致和"},{"creatorName":"コマダ, ムネカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長尾, 哲二"},{"creatorName":"ナガオ, テツジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-11-08"}],"displaytype":"detail","filename":"17K08500seika.pdf","filesize":[{"value":"78.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K08500seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/22110/files/17K08500seika.pdf"},"version_id":"bb8a3d84-e1f2-4313-b538-2693be071191"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ミクログリア","subitem_subject_scheme":"Other"},{"subitem_subject":"脳内炎症","subitem_subject_scheme":"Other"},{"subitem_subject":"大脳皮質","subitem_subject_scheme":"Other"},{"subitem_subject":"海馬歯状回","subitem_subject_scheme":"Other"},{"subitem_subject":"神経新生","subitem_subject_scheme":"Other"},{"subitem_subject":"母胎内環境","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳構築におけるミクログリアの変遷機序とその意義の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳構築におけるミクログリアの変遷機序とその意義の解明","subitem_title_language":"ja"},{"subitem_title":"Elucidation of the mechanism of microglial transition in brain construction and its significance","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4710"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-11-08"},"publish_date":"2021-11-08","publish_status":"0","recid":"22110","relation_version_is_last":true,"title":["脳構築におけるミクログリアの変遷機序とその意義の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-08-02T06:22:41.154995+00:00"}