| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2021-10-29 |
| タイトル |
|
|
タイトル |
<Originals> Lusutrombopag effectively promotes the growth and differentiation of megakaryocytic cells from patients with myelodysplastic syndrome |
|
言語 |
en |
| 著者 |
Sano, Keigo
Tanaka, Hirokazu
J., Luis Espinoza
Kumode, Takahiro
Serizawa, Kentaro
Fujiwara, Ryosuke
Fukui, Ayano
Morita, Yasuyoshi
Hanamoto, Hitoshi
Matsumura, Itaru
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
lusutrombopag, thrombopoietin receptor, hematopoiesis, megakaryopoiesis, myelodysplastic syndrome |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| ID登録 |
|
|
ID登録 |
10.15100/00022070 |
|
ID登録タイプ |
JaLC |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 著者 所属 |
|
|
値 |
Department of Hematology, Kindai Nara hospital |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Faculty of Medicine, Kindai University |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
Kindai University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY
巻 46,
号 2,
p. 43-55,
発行日 2021-12
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
24327166 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Background: Thrombopoietin (TPO) and its receptor, c-Mpl are essential for megakaryopoiesis. Two TPO receptor agonists (TPO-RAs),Eltrombopag (ETP) and Romiplostim (Rom), which also activate c-Mpl, thereby transmitting signals to downstream molecules, are currently used for immune thrombocytopenia purpura and aplastic anemia. Furthermore, recent clinical trials demonstrated that ETP and Rom would be useful for Myelodysplastic syndromes (MDS) patients with thrombocytopenia. Lusutrombopag (LTP) is a novel TPO-RA, which is approved for thrombocytopenia associated with liver diseases. In this study, we examined the effects of LTP on the growth and differentiation of MDS CD34+ cells as a preclinical study. Method: Effects of LTP on the proliferation, differentiation, and long-term self-renewal activities of bone marrow CD34+ cells from MDS patients were assessed with liquid cultures, CFU-megakaryocyte assays, and serial replating assays, respectively. We also analyzed the effects of LTP on cytokine secretion from cultured MDS CD34+ cells with a cytokine antibody array. Results: LTP effectively promotes the growth and differentiation of MDS CD34+ cells with comparable efficacy to that exerted on CD34+ cells from healthy controls. The megakaryopoietic potential of LTP was comparable to that exerted by ETP and TPO. LTP did not stimulate growth of CD34+ MDS/AML blasts, a concern that has been associated with ETP and Rom. Both ETP and TPO induced higher levels of FGF7 than LTP from CD34+ MDS cells. Conclusion: Although LTP and ETP revealed some different biologic activities, LTP would be as effective as ETP in promoting the growth and megakaryocytic differentiation of MDS CD34+ cells. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20211200-0043.pdf (1.9 MB)
