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<Originals> Bone regeneration using an OCP/collagen composite supplemented with a bFGF drug delivery system: Evaluation in a rat calvarial bone defect model
https://doi.org/10.15100/00022069
https://doi.org/10.15100/00022069b48bb4e5-8499-480f-b187-588907341cf3
| 名前 / ファイル | ライセンス | アクション |
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AA0050842X-20211200-0029.pdf (1.6 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2021-10-29 | |||||||||
| タイトル | ||||||||||
| タイトル | <Originals> Bone regeneration using an OCP/collagen composite supplemented with a bFGF drug delivery system: Evaluation in a rat calvarial bone defect model | |||||||||
| 言語 | en | |||||||||
| 著者 |
Nagumo, Yoshiaki
× Nagumo, Yoshiaki
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | OCP/collagen, bFGF sustained release system, calvarial bone defect, osteogenesis | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| ID登録 | ||||||||||
| ID登録 | 10.15100/00022069 | |||||||||
| ID登録タイプ | JaLC | |||||||||
| 著者 所属 | ||||||||||
| 値 | Department of Plastic and Reconstructive Surgery, Kindai University Faculty of Medicine | |||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | Kindai University Medical Association | |||||||||
| 書誌情報 |
en : ACTA MEDICA KINDAI UNIVERSITY 巻 46, 号 2, p. 29-41, 発行日 2021-12 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 24327166 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | [Abstract] Bone regeneration methods using biomaterials, such as a bioactive ceramic (hydroxyapatite)and bioabsorbable ceramic (β-tricalcium phosphate), have been clinically applied as reconstruction materials for various bone defects. However, bone formation by these ceramics is limited in tissue engineering approaches. An octacalcium phosphate (OCP)/collagen (Col)-conjugated composite is biodegradable and highly osteoconductive, with OCP particles within Col enhancing the migration of osteoblasts, and, thus, it has potential as a new bone regeneration material. However, the application of exogenous osteogenic cytokines with this material has not yet been examined. In the present study, basic fibroblast growth factor (bFGF) delivered by biodegradable gelatin hydrogels for sustained release was incorporated into the OCP/Col composite, and the bone regeneration ability of this system was investigated in a rat calvarial defect model. Histological, immunohistochemical, and CT examinations revealed that new bone formation was markedly greater by the OCP/Col composite with the bFGF drug delivery system than by the OCP/Col composite alone. The present results demonstrate the potential of OCP/Col with the bFGF drug delivery system for the treatment of difficult bone defects. | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
