{"created":"2023-06-20T16:49:22.444891+00:00","id":21573,"links":{},"metadata":{"_buckets":{"deposit":"3c21e95b-f856-4027-9438-c8cce2d7fd78"},"_deposit":{"created_by":3,"id":"21573","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21573"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021573","sets":["14:923:2219:4653"]},"author_link":["36883","36882","36881","36884","36880","36885"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-03-31","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"26","bibliographicPageEnd":"18","bibliographicPageStart":"11","bibliographic_titles":[{"bibliographic_title":"近畿大学先端技術総合研究所紀要"},{"bibliographic_title":"Memoirs of Institute of Advanced Technology, Kindai University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[要旨]着床から胎盤形成までに形成される脱落膜は、着床胚に対する栄養分の輸送や胎児と母体間での免疫拒絶を防ぐ役割も担っている。その脱落膜形成において重要な働きをもつDEDD（Death effector-domain containing protein）は、子宮内における脱落膜細胞の分化に関係する。本実験では、初期の妊娠維持に重要とされるDeddの発現の検出をマウス微小滴採血により検出を試みた。自然交配により得られた妊娠個体は、非妊娠個体と比較し交配成立後5.5 日目に発現の上昇が認められた。さらに脱落膜形成後の妊娠期間(9.5,15.5 日)では発現の減少が確認され妊娠の成立および出産を確認した。これらのことから、微小採血を用いたDedd 発現を指標にした妊娠判定の可能性が示唆された。[Abstract] Decidualization, occurring between implantation and placenta formation, is a critical process for feeding nutrients to the embryo and the establishment of immunotolerance. DEDD (Death effector-domain containing protein) is involved in the differentiation of decidual menbrane in the uterus. In this study, we detected the expression of Dedd, which is important for maintaining early pregnancy, by infinitesimal blood and serum in mice. Continuous blood sampling and PCR analyses detected increased expression of the Dedd gene in pregnant females on 5.5 days post coitum. All pregnant females showed the decrease of Dedd expression on 9.5 and 15.5 days post coitum, and gave successful birth. These results suggest that Dedd is a potential marker to detect pregnancy by simple and easy PCR method.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学先端技術総合研究所"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13468693","subitem_source_identifier_type":"ISSN"}]},"item_2_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Anzai,Masayuki"},{"subitem_text_language":"en","subitem_text_value":"Fujino,Nao"},{"subitem_text_language":"en","subitem_text_value":"Hori,Kouichiro"},{"subitem_text_language":"en","subitem_text_value":"Ozaki,Miki"},{"subitem_text_language":"en","subitem_text_value":"Noda,Yoshihiro"},{"subitem_text_language":"en","subitem_text_value":"Matsumoto,Kazuya"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学先端技術総合研究所 :近畿大学大学院生物理工学研究科生物工学専攻"},{"subitem_text_value":"近畿大学生物理工学部遺伝子工学科"},{"subitem_text_value":"近畿大学生物理工学部遺伝子工学科"},{"subitem_text_value":"アドベンチャーワールド"},{"subitem_text_value":"（地独）東京都健康長寿医療センター研究所"},{"subitem_text_value":"近畿大学先端技術総合研究所 :近畿大学先大学院生物理工学研究科生物工学専攻 :近畿大学生物理工学部遺伝子工学科"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Institute of Advanced Technology, Kindai University :Division of Biological Science, Graduate School of Biology-Oriented Science and Technology, Kindai University"},{"subitem_text_value":"Faculty of Biology-Oriented Science and Technology, Kindai University"},{"subitem_text_value":"Faculty of Biology-Oriented Science and Technology, Kindai University"},{"subitem_text_value":"ADVENTURE WORLD"},{"subitem_text_value":"Tokyo Metropolitan Institute of Gerontology"},{"subitem_text_value":"Institute of Advanced Technology, Kindai University :Division of Biological Science, Graduate School of Biology-Oriented Science and Technology, Kindai University :Faculty of Biology-Oriented Science and Technology, Kindai University"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安齋, 政幸"},{"creatorName":"アンザイ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"藤野, 奈央"},{"creatorName":"フジノ, ナオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"堀, 光一郎"},{"creatorName":"ホリ, コウイチロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"尾崎, 美樹"},{"creatorName":"オザキ, ミキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"野田, 義博"},{"creatorName":"ノダ, ヨシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"松本, 和也"},{"creatorName":"マツモト, カズヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-25"}],"displaytype":"detail","filename":"AA11574630-20210331-0011.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA11574630-20210331-0011.pdf","url":"https://kindai.repo.nii.ac.jp/record/21573/files/AA11574630-20210331-0011.pdf"},"version_id":"119da1b9-15cf-468e-a4c4-353fc780c832"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"マウス","subitem_subject_scheme":"Other"},{"subitem_subject":"Dedd 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"脱落膜","subitem_subject_scheme":"Other"},{"subitem_subject":"mouse","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Dedd gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"decidual membrane","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈Research Note〉マウス血清を用いた初期の妊娠維持に必須なDedd 遺伝子の発現解析の一例","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈Research Note〉マウス血清を用いた初期の妊娠維持に必須なDedd 遺伝子の発現解析の一例"},{"subitem_title":"〈Research Note〉Expression analysis of the Dedd gene required maintenance of early pregnancy using mouse serum","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["4653"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-25"},"publish_date":"2021-03-25","publish_status":"0","recid":"21573","relation_version_is_last":true,"title":["〈Research Note〉マウス血清を用いた初期の妊娠維持に必須なDedd 遺伝子の発現解析の一例"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:06:36.428099+00:00"}