{"created":"2023-06-20T16:49:19.482337+00:00","id":21522,"links":{},"metadata":{"_buckets":{"deposit":"5f1bb990-f375-49e2-b2cb-ae97d248b5a6"},"_deposit":{"created_by":3,"id":"21522","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21522"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021522","sets":["14:2667:4613"]},"author_link":["43177"],"control_number":"21522","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K06140/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究は，赤血球による血管壁への押しつけと血管内皮の表面幾何形状の相互作用が好中球のローリング挙動に与える影響を明らかにすることを目的とする．本研究では，血管内腔の表面幾何形状を千鳥状に並んだ短い六角形柱で近似し，PDMS樹脂でパターンを作成した．そして，傾斜遠心顕微鏡を用いて，種々の押しつけ力の下でのHL-60細胞の挙動を観察した．正六角形と伸長・配向した六角形のパターンで比較した結果から，好中球が血管内皮細胞辺縁部を通過する割合は血管内皮細胞の形状には関係なく押しつけ力の大きさのみに依存すること，伸長した血管内皮細胞は細胞形状によるローリングの減速効果が小さいことが示唆された．研究成果の概要（英文）：The aim of this study is elucidation of correlative effects of pressing of neutrophils onto endothelium by collision with erythrocytes and surface topography of the endothelium on the neutrophils’ rolling behavior. In this study, the surface topography was modeled by staggered short hexagonal poles to make the model endothelium by PDMS. Behaviors of HL-60 cells on regular and elongated hexagonal patterns of the model endothelium were compared under a variety of pressing force using the inclined centrifuge microscope system. Consequently, it can be said that probability of neutrophils' passage through periphery of endothelial cells does not dependent on the endothelial cell shape but on the pressing force. Elongation of the endothelial cells, however, less affects deceleration of the rolling due to their slim shape.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K06140;   研究分野：流体工学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"Shirai, Atsushi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学工学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"白井, 敦"},{"creatorName":"シライ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43177","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20302226","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=20302226"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K06140seika.pdf","filesize":[{"value":"457.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K06140seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21522/files/17K06140seika.pdf"},"version_id":"8058cdbb-fe5a-4474-8a17-4ce26f750e70"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HL-60","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Rolling","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Surface topography","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Pressing force","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Endothelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血管内皮の表面幾何形状が好中球のローリング挙動に与える影響に関する実験的研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血管内皮の表面幾何形状が好中球のローリング挙動に与える影響に関する実験的研究","subitem_title_language":"ja"},{"subitem_title":"Influence of topography of vessel endothelium on rolling characteristics of neutrophils","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21522","relation_version_is_last":true,"title":["血管内皮の表面幾何形状が好中球のローリング挙動に与える影響に関する実験的研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T07:30:00.145338+00:00"}