{"created":"2023-06-20T16:49:18.905893+00:00","id":21509,"links":{},"metadata":{"_buckets":{"deposit":"2bdd02a4-449f-4004-be52-6de0bcef2037"},"_deposit":{"created_by":3,"id":"21509","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21509"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021509","sets":["14:2667:4613"]},"author_link":["43246"],"control_number":"21509","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18K15830/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：Aryl hydrocarbon receptor (AhR)は腸内細菌由来代謝産物や環境因子 (ダイオキシン・タバコの煙など) を認識する転写 因子であり、免疫システムの恒常性の維持に重要な役割を果たしている。「腸内細菌叢の変化に伴う細菌由来代謝産物のProfile変化」がAhRの活性化を介して、自己免疫性膵炎の発症を制御するという仮説を検証した結果、AhRリガンドである2, 3, 7, 8-Tetrachlorodibenzodioxin (TCDD)の投与あるいはIndole-3-pyruvic acid (IPA)の給餌により、自己免疫性膵炎の発症は抑制されることを見出した。研究成果の概要（英文）：Aryl hydrocarbon receptor (AhR) is a transcription factor that recognizes intestinal bacterial metabolites and environmental factors (dioxin, tobacco smoke, etc.) and plays an important role in maintaining homeostasis of the immune system. We verified the hypothesis that \" profile changes of bacterial metabolites associated with changes in intestinal flora\" regulate the evelopment of autoimmune pancreatitis through activation of AhR. As a result, administration of AhR ligands, 2, 3, 7, 8-Tetrachlorodibenzodioxin (TCDD) or the feeding of Indole-3-pyruvic acid (IPA) suppressed the onset of autoimmune pancreatitis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究;  研究期間：2018～2019;   課題番号：18K15830;   研究分野：消化器病態制御額;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAMATA, Ken"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 医学部講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"鎌田, 研"},{"creatorName":"カマタ, ケン","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"18K15830seika.pdf","filesize":[{"value":"200.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"18K15830seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21509/files/18K15830seika.pdf"},"version_id":"23c7bc26-e419-4828-90a9-6e00113400cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"自己免疫性膵炎","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"喫煙習慣からみたIgG4関連型自己免疫性膵炎の発症機序の解明と新規治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"喫煙習慣からみたIgG4関連型自己免疫性膵炎の発症機序の解明と新規治療法の開発","subitem_title_language":"ja"},{"subitem_title":"Elucidation of pathogenesis of IgG4-related autoimmune pancreatitis from the viewpoint of smoking habit and development of new treatment method","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21509","relation_version_is_last":true,"title":["喫煙習慣からみたIgG4関連型自己免疫性膵炎の発症機序の解明と新規治療法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T06:36:20.458606+00:00"}