{"created":"2023-06-20T16:49:18.817730+00:00","id":21507,"links":{},"metadata":{"_buckets":{"deposit":"f4548807-489f-4c61-9d94-e6a79c848456"},"_deposit":{"created_by":3,"id":"21507","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21507"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021507","sets":["14:2667:4613"]},"author_link":["43244"],"control_number":"21507","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"7","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K16493/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：マウスを使用し、非照射コントロール群、初回照射後12週の経過観察群、再照射のみ施行群(A群)、初回照射の7日後に再照射群(B群)、初回照射の12週後に再照射群(C群) に群分けし、初回照射の後に再照射を施行した。細胞死を含む陰窩の割合は、C群はA群よりも有意に少なかった。B群はA群・C群よりも同一陰窩での細胞死割合が高値であった。照射後細胞増殖はA群とC群で有意差を認めなかった。長期経過観察後の腹部への再照射後の急性期反応は細胞死、細胞増殖能ともに初回照射と同等であることを示した。再照射までの待機期間が短い場合には障害が増強されることが明らかになった。研究成果の概要（英文）：We aimed to elucidate the pathological findings following acute and late re-irradiation in a preclinical model. Mice were divided into five treatment groups: sham-irradiation (Sham-IR), 10-12 Gy (Single IR Acute), 15 Gy (Single IR Late), 15 Gy followed by10-12 Gy re-irradiation 7 days later (Re-IR Acute), or 15 Gy followed by 10-12 Gy re-irradiation 12 weeks later (Re-IR Late). Mice were sacrificed after either single irradiation or re-irradiation for pathological assessment. The Re-IR Late group had significantly lower numbers of crypts with apoptotic cells than those observed in mice in the Single IR Acute group. There were no significant differences between the Single IR Acute and re-IR Acute groups in cell proliferation or in a crypt survival assay. Re-irradiation with a long interval after the first irradiation may cause similar acute biological effects in normal intestine as observed following irradiation without re-irradiation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2017～2019;   課題番号：17K16493;   研究分野：放射線腫瘍学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"DOI, Hiroshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"土井, 啓至"},{"creatorName":"ドイ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43244","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50529047","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=50529047"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K16493seika.pdf","filesize":[{"value":"281.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K16493seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21507/files/17K16493seika.pdf"},"version_id":"763de410-2822-4e0d-93e7-7057ddbf3fbc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"再照射","subitem_subject_scheme":"Other"},{"subitem_subject":"強度変調放射線治療","subitem_subject_scheme":"Other"},{"subitem_subject":"定位放射線治療","subitem_subject_scheme":"Other"},{"subitem_subject":"動物実験モデル","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線治療","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線照射","subitem_subject_scheme":"Other"},{"subitem_subject":"マウスモデル","subitem_subject_scheme":"Other"},{"subitem_subject":"低酸素","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"放射線治療後再発に対する再照射実験モデルの確立－放射線感受性と生体応答の検証－","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"放射線治療後再発に対する再照射実験モデルの確立－放射線感受性と生体応答の検証－","subitem_title_language":"ja"},{"subitem_title":"Assessment of an experimental re-irradiation model","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21507","relation_version_is_last":true,"title":["放射線治療後再発に対する再照射実験モデルの確立－放射線感受性と生体応答の検証－"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T06:00:19.258437+00:00"}