{"created":"2023-06-20T16:49:18.684798+00:00","id":21504,"links":{},"metadata":{"_buckets":{"deposit":"70a68a72-3b02-4fce-93fc-6a982e79e0ef"},"_deposit":{"created_by":3,"id":"21504","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21504"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021504","sets":["14:2667:4613"]},"author_link":["31946","3989","3267"],"control_number":"21504","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11440/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：重症未熟児網膜症に対しranibizumab投与を行った22例43眼では20.9%で再燃がみられた。bevacizumab投与を行った21例37眼では13.5%の再燃率で、前者でやや再燃率がやや高い傾向がみられた（P=0.556）。多重ロジスティック解析で修正35週以下での抗VEGF治療 (OR, 7.524; 95% CI, 1.494–37.89; p= 0.014) と病型として aggressive posterior ROPであったこと (OR, 5.532; 95% CI, 1.049–29.17; p= 0.044)の2つが有意な要因であった。研究成果の概要（英文）：Anti-vascular endothelial growth factor (VEGF) therapy was performed for infants with severe retinopathy of prematurity (ROP). Reactivation was observed in 20.9% of 43 eyes of 22 infants after ranibizumab injection and 13.5% of 37 eyes of 21 infants after bevacizumab injection（P=0.556）. Multivariate logistic regression analyses revealed that anti-VEGF therapy at 35 weeks or younger post-conceptional age (OR, 7.524; 95% CI, 1.494–37.89; p = 0.014) and aggressive posterior ROP (OR, 5.532; 95% CI, 1.049–29.17; p = 0.044) were the significant risk factors for reactivation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C); 研究期間：2017～2019;   課題番号：17K11440;   研究分野：眼科　網膜硝子体疾患　小児網膜;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KUSAKA, Shunji"},{"subitem_text_language":"en","subitem_text_value":"KUNIYOSHI, Kazuki"},{"subitem_text_language":"en","subitem_text_value":"SUGIOKA, Koji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学大学病院; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"日下, 俊次"},{"creatorName":"クサカ, シュンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31946","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60260387","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=60260387"}]},{"creatorNames":[{"creatorName":"國吉, 一樹"},{"creatorName":"クニヨシ, カズキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3989","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"30234470","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=30234470"}]},{"creatorNames":[{"creatorName":"杉岡, 孝二"},{"creatorName":"スギオカ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3267","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50399119","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=50399119"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K11440seika.pdf","filesize":[{"value":"200.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K11440seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21504/files/17K11440seika.pdf"},"version_id":"11d24532-c81c-4c25-9a34-54995c56e566"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"未熟児網膜症","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮増殖因子","subitem_subject_scheme":"Other"},{"subitem_subject":"抗VEGF治療","subitem_subject_scheme":"Other"},{"subitem_subject":"VEGF","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜光凝固","subitem_subject_scheme":"Other"},{"subitem_subject":"低出生体重児","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"重症未熟児網膜症に対する抗血管内皮増殖因子治療の検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"重症未熟児網膜症に対する抗血管内皮増殖因子治療の検討","subitem_title_language":"ja"},{"subitem_title":"Anti-VEGF treatment for severe retinopathy of prematurity","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21504","relation_version_is_last":true,"title":["重症未熟児網膜症に対する抗血管内皮増殖因子治療の検討"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T05:49:09.461948+00:00"}