{"created":"2023-06-20T16:49:18.552584+00:00","id":21501,"links":{},"metadata":{"_buckets":{"deposit":"324f4609-d458-4565-b981-bc54c7c9a01f"},"_deposit":{"created_by":3,"id":"21501","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21501"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021501","sets":["14:2667:4613"]},"author_link":["3992","3356","3960","43238"],"control_number":"21501","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"9","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K11037/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：ヒトiPS細胞を臨床応用するには、より能力が高くまた安定した基底状態へ導く必要がある。本研究では、βcatenin分子に着目し、その修飾状態を変化させることで遺伝子組換えを経ず、また単一の因子の制御によって基底状態ヒトiPS細胞の獲得が可能であった。本研究成果は、多能性ネットワークの理解およびiPS細胞のさらなる利用価値を高める結果となる。また、βcateninは細胞の癌化や細胞死に強く関連することから、本研究により得られた新しいβcateninの機能は未知の細胞現象における一つの重要な知見となりうる。研究成果の概要（英文）：The clinical application for regenerative medicine of human iPS cells should be achieved to naive state which shows a more high differentiation potential, self-renwal and genome stability. In this study, we focused on the βcatenin molecule and found that the acquisition of naive human iPS cells was possible without genetic intervention and by altering its post-transcription modification state. These results will refinement the understanding of the pluripotency network and the value of using iPS cells further. In addition, since βcatenin is robustly associated with oncogenic transformation and cell death, the novel function of βcatenin obtained in this study may be an important insight in an unknown cellular phenomenon.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K11037;   研究分野：幹細胞生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TAKEHARA, Toshiyuki"},{"subitem_text_language":"en","subitem_text_value":"TERAMURA, Takeshi"},{"subitem_text_language":"en","subitem_text_value":"FUKUDA, Kanji"},{"subitem_text_language":"en","subitem_text_value":"SUEMORI, Hirofumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学病院; 助教"},{"subitem_text_value":"近畿大学大学病院; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"京都大学ウイルス・再生医科学研究所; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"竹原, 俊幸"},{"creatorName":"タケハラ, トシユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3992","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60580561","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=60580561"}]},{"creatorNames":[{"creatorName":"寺村, 岳士"},{"creatorName":"テラムラ, タケシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3356","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"40460901","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=40460901"}]},{"creatorNames":[{"creatorName":"福田, 寛二"},{"creatorName":"フクダ, カンジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3960","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50201744","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=50201744"}]},{"creatorNames":[{"creatorName":"末盛, 博文"},{"creatorName":"スエモリ, ヒロフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"43238","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90261198","nameIdentifierScheme":"NRID","nameIdentifierURI":"https://nrid.nii.ac.jp/ja/search/?kw=90261198"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K11037seika.pdf","filesize":[{"value":"517.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K11037seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21501/files/17K11037seika.pdf"},"version_id":"43b044ce-47a0-4bdb-b2b1-2020807bf16d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"βcatenin","subitem_subject_scheme":"Other"},{"subitem_subject":"naive型とprimed型","subitem_subject_scheme":"Other"},{"subitem_subject":"多能性幹細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"iPS細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"基底状態","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"β-cateninを標的とした未分化性制御による新規多能性幹細胞の作製法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"β-cateninを標的とした未分化性制御による新規多能性幹細胞の作製法の開発","subitem_title_language":"ja"},{"subitem_title":"Acquisition of novel naive pluripotent stem cells by activation and regulation of post-transcriptional modification on beta catenin","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21501","relation_version_is_last":true,"title":["β-cateninを標的とした未分化性制御による新規多能性幹細胞の作製法の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T05:19:48.928521+00:00"}