{"created":"2023-06-20T16:49:18.242716+00:00","id":21494,"links":{},"metadata":{"_buckets":{"deposit":"47ee7656-5c4b-44c9-b636-0e400e38a3f1"},"_deposit":{"created_by":3,"id":"21494","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"21494"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00021494","sets":["14:2667:4613"]},"author_link":["30513","30510","43226","43227"],"control_number":"21494","item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2019)"}]}]},"item_8_description_25":{"attribute_name":"リンクURL","attribute_value_mlt":[{"subitem_description":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10320/","subitem_description_type":"Other"}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：統合失調症の病態を指し示すことのできるバイオマーカーを探すため、聴性定常反応を利用した脳波測定とnear-infrared spectroscopy（NIRS）を用いた安静時脳血流の測定をおこなった。NIRSを用いた安静時脳血流では、安静時脳血流の定量法としてfMRIで用いられているamplitude of low frequency fluctuations (ALFF)やfractional ALFF(fALFF)の解析手法をNIRSに応用し、慢性期の統合失調症患者の前頭前野の内側部でALFF、fALFFともに減少しており、さらにALFFは幻聴の症状と負の相関を示すことを新たに見出した。研究成果の概要（英文）：We measured the auditory steady state response (ASSR) using electroencephalography (EEG) and the cerebral blood flow at rest using near-infrared spectroscopy （NIRS）to identify a biomarker for the pathophysiology of the prefrontal cortex in schizophrenia. In the analysis of the cerebral blood flow during resting-state, we applied the methods of the amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF), which have been used in fMRI studies to quantify the resting-state blood flow, to the NIRS data. We found that both ALFF and fALFF were decreased in the medial prefrontal cortex of the chronic patients with schizophrenia, and that the ALFF was negatively associated with the symptoms of auditory hallucinations in the patients.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K10320;   研究分野：精神医学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YANAGI, Masaya"},{"subitem_text_language":"en","subitem_text_value":"SHIRAKAWA, Osamu"},{"subitem_text_language":"en","subitem_text_value":"HOSOMI, Fumiharu"},{"subitem_text_language":"en","subitem_text_value":"KAWAKUBO, Yoshihiro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"柳, 雅也"},{"creatorName":"ヤナギ, マサヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"白川, 治"},{"creatorName":"シラカワ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"細見, 史治"},{"creatorName":"ホソミ, フミハル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川久保, 善宏"},{"creatorName":"カワクボ, ヨシヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2021-03-15"}],"displaytype":"detail","filename":"17K10320seika.pdf","filesize":[{"value":"169.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"17K10320seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/21494/files/17K10320seika.pdf"},"version_id":"fbac0f1c-60ea-4ed5-88a9-8ddc85cc076a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"統合失調症","subitem_subject_scheme":"Other"},{"subitem_subject":"前頭前野","subitem_subject_scheme":"Other"},{"subitem_subject":"聴性定常反応","subitem_subject_scheme":"Other"},{"subitem_subject":"安静時脳血流","subitem_subject_scheme":"Other"},{"subitem_subject":"NIRS","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"Kv3.1/3.2遺伝子変異を利用した統合失調症の病態評価指標の同定","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Kv3.1/3.2遺伝子変異を利用した統合失調症の病態評価指標の同定","subitem_title_language":"ja"},{"subitem_title":"Identification of a biomarker for pathophysiology of schizophrenia using Kv3.1/3.2 gene mutations","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4613"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2021-03-15"},"publish_date":"2021-03-15","publish_status":"0","recid":"21494","relation_version_is_last":true,"title":["Kv3.1/3.2遺伝子変異を利用した統合失調症の病態評価指標の同定"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-14T02:54:04.398614+00:00"}