@techreport{oai:kindai.repo.nii.ac.jp:00021494,
 author = {柳, 雅也 and 白川, 治 and 細見, 史治 and 川久保, 善宏},
 month = {},
 note = {https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17K10320/, 研究成果の概要（和文）：統合失調症の病態を指し示すことのできるバイオマーカーを探すため、聴性定常反応を利用した脳波測定とnear-infrared spectroscopy（NIRS）を用いた安静時脳血流の測定をおこなった。NIRSを用いた安静時脳血流では、安静時脳血流の定量法としてfMRIで用いられているamplitude of low frequency fluctuations (ALFF)やfractional ALFF(fALFF)の解析手法をNIRSに応用し、慢性期の統合失調症患者の前頭前野の内側部でALFF、fALFFともに減少しており、さらにALFFは幻聴の症状と負の相関を示すことを新たに見出した。研究成果の概要（英文）：We measured the auditory steady state response (ASSR) using electroencephalography (EEG) and the cerebral blood flow at rest using near-infrared spectroscopy （NIRS）to identify a biomarker for the pathophysiology of the prefrontal cortex in schizophrenia. In the analysis of the cerebral blood flow during resting-state, we applied the methods of the amplitude of low frequency fluctuations (ALFF) and fractional ALFF (fALFF), which have been used in fMRI studies to quantify the resting-state blood flow, to the NIRS data. We found that both ALFF and fALFF were decreased in the medial prefrontal cortex of the chronic patients with schizophrenia, and that the ALFF was negatively associated with the symptoms of auditory hallucinations in the patients., 研究種目：基盤研究(C);  研究期間：2017～2019;   課題番号：17K10320;   研究分野：精神医学;   科研費の分科・細目：, application/pdf},
 title = {Kv3.1/3.2遺伝子変異を利用した統合失調症の病態評価指標の同定},
 year = {2020},
 yomi = {ヤナギ, マサヤ and シラカワ, オサム and ホソミ, フミハル and カワクボ, ヨシヒロ}
}